We present a microfluidic method to continuously produce multicompartment microfibers, where embedded single or double emulsion droplets are regularly spaced along the length of the fiber. Both hydrophobic and hydrophilic compounds can be encapsulated in different microcompartments of the fiber for storage, selective dissolution, and delivery applications, as well as to provide multifunctionality.
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http://dx.doi.org/10.1039/c4tb01666a | DOI Listing |
ACS Appl Mater Interfaces
November 2022
Division of Engineering in Medicine, Department of Medicine, Harvard Medical School, and Brigham and Women's Hospital, Cambridge, Massachusetts 02139, United States.
Recapitulating inherent heterogeneity and complex microarchitectures within confined print volumes for developing implantable constructs that could maintain their structure has remained challenging. Here, we present a combinational multimaterial and embedded bioprinting approach to fabricate complex tissue constructs that can be implanted postprinting and retain their three-dimensional (3D) shape . The microfluidics-based single nozzle printhead with computer-controlled pneumatic pressure valves enables laminar flow-based voxelation of up to seven individual bioinks with rapid switching between various bioinks that can solve alignment issues generated during switching multiple nozzles.
View Article and Find Full Text PDFJ Mater Chem B
December 2014
Department of Mechanical and Aerospace Engineering, Princeton University, Princeton, NJ 08544, USA.
We present a microfluidic method to continuously produce multicompartment microfibers, where embedded single or double emulsion droplets are regularly spaced along the length of the fiber. Both hydrophobic and hydrophilic compounds can be encapsulated in different microcompartments of the fiber for storage, selective dissolution, and delivery applications, as well as to provide multifunctionality.
View Article and Find Full Text PDFAdv Mater
August 2014
State Key Laboratory of Bioelectronics, Southeast University, Nanjing, 210096, China.
Bioinspired multicompartmental microfibers are generated by novel capillary microfluidics. The resultant microfibers possess multicompartment body-and-shell compositions with specifically designed geometries. Potential use of these microfibers for tissue-engineering applications is demonstrated by creating multifunctional fibers with a spatially controlled encapsulation of cells.
View Article and Find Full Text PDFMacromol Rapid Commun
December 2012
Max Planck Institute for Polymer Research, Ackermannweg 10, 55128 Mainz, Germany.
Solution-, melt-, and co-axial electrospinning are well-known methods for producing nano- and microfibers. The electrospinning of colloids (or colloid-electrospinning) is a new field that offers the possibility to elaborate multicompartment nanomaterials. However, the presence of colloids in the electrospinning feed further complicates theoretical predictions in a system that is dependent on chemical, physical, and process parameters.
View Article and Find Full Text PDFEnter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!