Multifunctional star-shaped polylactic acid implants for use in angioplasty.

J Mater Chem B

Materials Science and Technology Division, National Institute for Interdisciplinary Science and Technology, Pappanamcode, Thiruvananthapuram-695019, India.

Published: October 2014

Towards the development of new biomaterials for use in angioplasty, star-shaped polylactic acids have been synthesised and shown to adhere well to living cells, by in vitro and in vivo experiments, and to hydrolyse over time in a physiologically relevant environment into biocompatible and bioabsorbable entities that are capable of bestowing properties of anticoagulation and angiogenesis to their living host.

Download full-text PDF

Source
http://dx.doi.org/10.1039/c4tb00272eDOI Listing

Publication Analysis

Top Keywords

star-shaped polylactic
8
multifunctional star-shaped
4
polylactic acid
4
acid implants
4
implants angioplasty
4
angioplasty development
4
development biomaterials
4
biomaterials angioplasty
4
angioplasty star-shaped
4
polylactic acids
4

Similar Publications

The retention capacity of polymers is related to the development of systems that combine high surface-to-volume ratio with good handling and specific functionality. Biodegradability and biocompatibility are also key features for extending the field of applications to areas such as biomedicine. With this in mind, the aim of this work is to develop biodegradable, biocompatible, and highly functionalized porous films, that ensure suitable handling and a good surface-to-volume ratio.

View Article and Find Full Text PDF
Article Synopsis
  • The study explores the use of N-coordinated tin(ii) cations as catalysts for ring-opening polymerization (ROP) to produce well-defined linear poly(ε-caprolactone) (PCL) and poly(δ-valerolactone) (PVL).
  • These catalysts also enable the synthesis of star-shaped polymers with varying functionalities, which were analyzed for their structural properties using SEC-MALS-Visco.
  • To enhance hydrophobicity, new stannaboroxines were tested, showing potential improvements in the water resistance of the resulting polymers.
View Article and Find Full Text PDF

This work aims at improving and disclosing new properties of films based on polylactic acid (PLA) and a star-shaped polycaprolactone (PCL). Indeed, previous works demonstrated that the presence of ad-hoc synthesized PCL, characterized by low molecular weight and carboxyl end groups (coded as PCL-COOH), improves the elongation at break of the films compared to that of neat PLA and increases their functionality. To further improve the properties of the system, alternating layers of chitosan (CH) and DNA were deposited on the surface applying a Layer-by-Layer (LbL) technique.

View Article and Find Full Text PDF

The design of a biomimetic scaffold is a major challenge in tissue engineering to promote tissue reconstruction. The use of synthetic polymer nanofibers is widely described as they provide biocompatible matrices whose topography mimics natural extracellular matrix (ECM). To closely match the biochemical composition of the ECM, bioactive molecules such as gelatin are added to the nanofibers to enhance cell adhesion and proliferation.

View Article and Find Full Text PDF

To obtain fully degradable and super-tough poly(lactide-co-glycolide) (PLGA) blends, biodegradable star-shaped PCL--PDLA plasticizers were synthesized using natural originated xylitol as initiator. These plasticizers were blended with PLGA to prepare transparent thin films. Effects of added star-shaped PCL--PDLA plasticizers on mechanical, morphological, and thermodynamic properties of PLGA/star-shaped PCL--PDLA blends were investigated.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!