Towards the development of new biomaterials for use in angioplasty, star-shaped polylactic acids have been synthesised and shown to adhere well to living cells, by in vitro and in vivo experiments, and to hydrolyse over time in a physiologically relevant environment into biocompatible and bioabsorbable entities that are capable of bestowing properties of anticoagulation and angiogenesis to their living host.
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http://dx.doi.org/10.1039/c4tb00272e | DOI Listing |
Macromol Biosci
December 2024
Dipartimento di Chimica e Chimica Industriale, Università degli studi di Genova, via Dodecaneso 31, Genoa, 16146, Italy.
The retention capacity of polymers is related to the development of systems that combine high surface-to-volume ratio with good handling and specific functionality. Biodegradability and biocompatibility are also key features for extending the field of applications to areas such as biomedicine. With this in mind, the aim of this work is to develop biodegradable, biocompatible, and highly functionalized porous films, that ensure suitable handling and a good surface-to-volume ratio.
View Article and Find Full Text PDFRSC Adv
July 2024
Department of General and Inorganic Chemistry, Faculty of Chemical Technology, University of Pardubice Studentská 573 53210 Pardubice Czech Republic.
Colloids Surf B Biointerfaces
April 2024
Dipartimento di Chimica e Chimica Industriale, Università di Genova, Via Dodecaneso, 31, Genova 16146, Italy. Electronic address:
This work aims at improving and disclosing new properties of films based on polylactic acid (PLA) and a star-shaped polycaprolactone (PCL). Indeed, previous works demonstrated that the presence of ad-hoc synthesized PCL, characterized by low molecular weight and carboxyl end groups (coded as PCL-COOH), improves the elongation at break of the films compared to that of neat PLA and increases their functionality. To further improve the properties of the system, alternating layers of chitosan (CH) and DNA were deposited on the surface applying a Layer-by-Layer (LbL) technique.
View Article and Find Full Text PDFNanotechnology
September 2023
Polymers for Health and Biomaterials, IBMM, University of Montpellier, CNRS, ENSCM, Montpellier, France.
The design of a biomimetic scaffold is a major challenge in tissue engineering to promote tissue reconstruction. The use of synthetic polymer nanofibers is widely described as they provide biocompatible matrices whose topography mimics natural extracellular matrix (ECM). To closely match the biochemical composition of the ECM, bioactive molecules such as gelatin are added to the nanofibers to enhance cell adhesion and proliferation.
View Article and Find Full Text PDFPolymers (Basel)
June 2023
School of Chemical Engineering, Sungkyunkwan University, Suwon 16419, Republic of Korea.
To obtain fully degradable and super-tough poly(lactide-co-glycolide) (PLGA) blends, biodegradable star-shaped PCL--PDLA plasticizers were synthesized using natural originated xylitol as initiator. These plasticizers were blended with PLGA to prepare transparent thin films. Effects of added star-shaped PCL--PDLA plasticizers on mechanical, morphological, and thermodynamic properties of PLGA/star-shaped PCL--PDLA blends were investigated.
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