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Graphitic-phase CN nanosheets as efficient photosensitizers and pH-responsive drug nanocarriers for cancer imaging and therapy. | LitMetric

Graphitic-phase CN nanosheets as efficient photosensitizers and pH-responsive drug nanocarriers for cancer imaging and therapy.

J Mater Chem B

The Key Lab of Analysis and Detection Technology for Food Safety of the MOE, Fujian Provincial Key Laboratory of Analysis and Detection Technology for Food Safety, College of Chemistry and Chemical Engineering, Fuzhou University, Fuzhou 350108, P.R. China.

Published: February 2014

AI Article Synopsis

Article Abstract

Graphitic-phase carbon nitride (g-CN) nanosheets, the newly emerging two-dimensional (2D) layered nanomaterials, have been demonstrated to be promising bioimaging agents due to their high photoluminescence (PL) quantum yields, good biocompatibility and low toxicity. However, the therapeutic applications of g-CN nanosheets have not been explored until now. In this study, we have proven for the first time that g-CN nanosheets can be used as efficient photosensitizers for photodynamic tumor therapy and as pH-responsive nanocarriers for drug delivery. On one hand, as photosensitizers, g-CN nanosheets are able to generate reactive oxygen species (ROS) and kill cancer cells efficiently under low-intensity light irradiation (20 mW cm). On the other hand, as nanocarriers, g-CN nanosheets possess an ultrahigh drug-loading capacity owing to their high surface-to-volume ratio. More importantly, g-CN nanosheets loaded with the anticancer drug doxorubicin (DOX) exhibit a pH-responsive release property which is beneficial for the delivery of DOX into cancer cells for chemotherapy. Furthermore, due to their high PL quantum yields, the fluorescent g-CN nanosheets can enable visualization of the delivery. These findings demonstrated the potential of g-CN nanosheets as low-toxic and biocompatible photosensitizers and pH-responsive drug nanocarriers for biomedical applications.

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Source
http://dx.doi.org/10.1039/c3tb21479fDOI Listing

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