In this study we developed simple reactions that combined microwave plasma reactions in the presence of maleic anhydride with alkyne click chemistries to achieve a platform for unlimited possibilities for further surface modifications of aliphatic polymer surfaces. Using this approach, we covalently attached ampicillin (AMP) to polyethylene (PE) and polypropylene (PP) substrates. As a result, high efficacy against microbial film formation, manifested by efficient antimicrobial activity against S. aureus with a 97-99.8% decrease of bacterial growth, was achieved. This simple and clean process allows functionalization of any polymeric substrate without adverse effects on bulk polymer properties.
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| http://dx.doi.org/10.1039/c3tb21865a | DOI Listing |
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