The first example of silicon nanowire (SiNW)-based in vivo tumor phototherapy is presented. Gold nanoparticle (AuNP)-decorated SiNWs are employed as high-performance NIR hyperthermia agents for highly efficacious in vivo tumour ablation. Significantly, the overall survival time of SiNW-treated mice is drastically prolonged, with 100% of mice being alive and tumor-free for over 8 months, which is the longest survival time ever reported for tumor-bearing mice treated with nanomaterial-based NIR hyperthermia agents.
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