Analysis of Gene Expression of miRNA-106b-5p and in the Apoptosis Pathway in Gastric Cancer.

() is one of the main causes of gastric gancer. is a protein able to promote apoptosis in cancer cells, however not in gastric cancer, which presents resistance to apoptosis via . It is believed that MicroRNA-106b-5p might be involved in this resistance, although its role in Gastric Cancer is unclear. We aimed to determine the expression of microRNA-106b-5p and in patients with gastric diseases, infected by , and understand the relationship between these genes and their role in apoptosis and the gastric cancer pathways. was detected by PCR, gene expression analysis was performed by real-time-qPCR, and bioinformatics analysis was performed using the Kyoto Encyclopedia of Genes and Genomes (KEGG) and Cytoscape software. A total of 244 patients were divided into groups (Control, Gastritis, and Cancer); was detected in 42.2% of the samples. The cancer group had a poor expression of ( < 0.0001) and overexpression of microRNA-106b-5p (), however, our results confirmed that these genes are not directly related to each other although both are apoptosis-related regulators. Our results also indicated that decreases microRNA-106b-5p expression and that this is a carcinogenic bacterium responsible for gastric diseases.