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| http://dx.doi.org/10.1016/j.jdcr.2020.01.024 | DOI Listing |
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Other (Non-CNS/Testicular) Extramedullary Localizations of Childhood Relapsed Acute Lymphoblastic Leukemia and Lymphoblastic Lymphoma-A Report from the ALL-REZ Study Group.
J Clin Med
November 2021
Department of Pediatric Hematology and Oncology, Charité-Universitätsmedizin Berlin, Augstenburger Platz 1, 13353 Berlin, Germany.
Unlabelled: Children with other extramedullary relapse of acute lymphoblastic leukemia are currently poorly characterized. We aim to assess the prevalence and the clinical, therapeutic and prognostic features of extramedullary localizations other than central nervous system or testis in children with relapse of acute lymphoblastic leukemia (ALL) and lymphoblastic lymphoma (LBL) treated on a relapsed ALL protocol.
Patients And Methods: Patients with relapse of ALL and LBL, treated according to the multicentric ALL-REZ BFM trials between 1983 and 2015, were analyzed for other extramedullary relapse (OEMR) of the disease regarding clinical features, treatment and outcome.
Expression of YY1 in pro-B and T phenotypes correlation with poor survival in pediatric acute lymphoblastic leukemia.
Pediatr Hematol Oncol
August 2021
Oncology Disease Research Unit, Children's Hospital of Mexico, Federico Gomez, Mexico City, Mexico.
Acute lymphoblastic leukemia (ALL) is the most common pediatric cancer, constituting 80% of all acute leukemias in minors. Despite the increase in the success of therapies, disease-free survival is over 80% in most cases. For the remaining 20% of patients, new strategies are needed to allow us to know and select those at greatest risk of relapse.
View Article and Find Full Text PDFT-immunophenotype lymphoblastic lymphoma with secondary cutaneous involvement associated with rapid regression followed up with positron emission tomography.
JAAD Case Rep
April 2020
Dermatology, Sírio-Libanês Hospital, São Paulo, Brazil.
A strategy for the clinical remission of acute lymphoblastic leukemia elicited by treatment of β-thalassemia major: A case report.
Mol Clin Oncol
February 2018
Department of Hematology, Hospital Infantil de México Federico Gómez, Mexico City 06720, Mexico.
Acute lymphoblastic leukemia (ALL) has been suggested as a long-term complication in patients with β-thalassemia major (β-TM). A 12-months-old male patient was diagnosed with β-TM. The patient required a blood transfusion weekly for 2 years.
View Article and Find Full Text PDFG80A Single Nucleotide Polymorphism in Reduced Folate Carrier-1 Gene in a Mexican Population and its Impact on Survival in Patients with Acute Lymphoblastic Leukemia.
Rev Invest Clin
July 2017
Instituto de Investigaciones Biomédicas, UNAM and Instituto Nacional de Cancerología, Mexico City, Mexico.
Background: Hyper-CVAD is the treatment for patients with acute lymphoblastic leukemia in our institution.
Objective: To evaluate the impact of single nucleotide polymorphisms at genes associated with methotrexate metabolism on survival.
Methods: The presence of the single nucleotide polymorphisms G80A at reduced folate carrier-1 gene and C677T in the methylenetetrahydrofolate reductase gene was determined by denaturing high performance liquid chromatography and validated by sequencing.
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