[This corrects the article DOI: 10.1038/boneres.2017.44.].
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Antimicrobials are among the most commonly prescribed classes of medications in Neonatal Intensive Care Units; however, its use has been constantly associated with a number of medication errors in clinical practice. In contrast to this situation, there is no common agreement when it comes to determining the right dosing, administration, or handling of antibiotics in this population. In order to help improve the use of antibiotics, decrease the rate of medication errors and optimize clinical results in the newborn, this review aims to provide recommendations to support and guide the correct preparation of some of the most relevant antibiotics used in neonatal wards.
View Article and Find Full Text PDFProgrammed cell fusion in development and homeostasis.
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March 2022
Department of Biology, Technion-Israel Institute of Technology, Haifa, Israel. Electronic address:
During multicellular organism development, complex structures are sculpted to form organs and tissues, which are maintained throughout adulthood. Many of these processes require cells to fuse with one another, or with themselves. These plasma membrane fusions merge endoplasmic cellular content across external, exoplasmic, space.
View Article and Find Full Text PDFCorrection to: AFF1 and AFF4 differentially regulate the osteogenic differentiation of human MSCs.
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1State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China.
[This corrects the article DOI: 10.1038/boneres.2017.
View Article and Find Full Text PDFApplying Nightingale charts to evaluate the heterogeneity of biomedical waste in a Hospital.
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December 2016
Universidade de Caxias do Sul, Caxias do Sul, RS, Brazil.
Objectives: to evaluate the heterogeneity of biomedical waste (BW) using Nightingale charts.
Method: cross-sectional study consisting of data collection on wastes (direct observation of receptacles, physical characterisation, and gravimetric composition), development of a Management Information System, and creation of statistical charts.
Results: the wastes with the greatest degree of heterogeneity are, in order, recyclable, infectious, and organic wastes; chemical waste had the most efficient segregation; Nightingale charts are useful for quick visualisation and systematisation of information on heterogeneity.
Extracellular vesicles: a platform for the structure determination of membrane proteins by Cryo-EM.
Structure
November 2014
Division of Structural Biology, Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK. Electronic address:
Membrane protein-enriched extracellular vesicles (MPEEVs) provide a platform for studying intact membrane proteins natively anchored with the correct topology in genuine biological membranes. This approach circumvents the need to conduct tedious detergent screens for solubilization, purification, and reconstitution required in classical membrane protein studies. We have applied this method to three integral type I membrane proteins, namely the Caenorhabditis elegans cell-cell fusion proteins AFF-1 and EFF-1 and the glycoprotein B (gB) from Herpes simplex virus type 1 (HSV1).
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