Aim: To demonstrate that myrrh oil preferentially kills nongrowing bacteria and causes no resistance development.
Method: Growth inhibition was determined on regular plates or plates without nutrients, which were later overlaid with soft agar containing nutrients to continue growth. Killing experiments were done in broth and in buffer without nutrients.
Results: Bacterial cells were inhibited preferentially in the absence of nutrients or when growth was halted by a bacteriostatic antibiotic. After five passages in myrrh oil, surviving colonies showed no resistance to the antibiotic.
Conclusion: Myrrh oil has the potential to be a commercially viable antibiotic that kills persister cells and causes no resistance development. This is a rare example of an antibiotic that can preferentially kill nongrowing bacteria.
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| http://dx.doi.org/10.2144/fsoa-2019-0121 | DOI Listing |
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- * They discovered that antibiotic exposure generates ROS, which can worsen bacterial death, and identified that the enzyme KatG is critical for the survival of persister cells under certain conditions, particularly in nutrient-deprived environments.
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