The presence of type-II thyroxine 5'-deiodinase (5'-D) activity in rat pineal gland has been previously described. In the present paper, 5'-D activity, N-acetyltransferase (NAT) activity, and melatonin content were measured in the same rat pineal. Each of these constituents exhibits a nocturnal increase with peak values at 0100 h for melatonin (1.20 +/- 0.12 ng/gland) and at 0300 h for both 5'-D (39.5 +/- 11.9 fmol/gland/h) and NAT (8.38 +/- 1.04 nmol/gland/h) activities. In vivo treatment with iopanoic acid (IOP) completely prevented the nocturnal increase in 5'-D activity (14.1 +/- 2.6 fmol/gland/h at 0300 h) with no modification in either the NAT activity or melatonin content. Thyroidectomy greatly enhanced the 5'-D activity during the dark period (102.9 +/- 10.2 vs. 31.6 +/- 4.2 fmol/gland/h), reaching a peak at 0200 h; thyroidectomy, however, did not affect daytime pineal 5'-D activity (3.11 +/- 0.78 vs. 2.5 + 0.92 fmol/gland/h). Treatment of rats with IOP acid completely inhibited the pineal 5'-D activity in both control (7.86 +/- 0.88 fmol/gland/h) and thyroidectomized animals (2.24 +/- 1.10 fmol/gland/h) with no change in the melatonin content of the gland (1.21 +/- 0.32 vs. 0.99 +/- 0.18 ng/gland).
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1111/j.1600-079x.1988.tb00793.x | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
[Homer 1a overexpression alleviates nerve injury in mice with traumatic brain injury by regulating autophagy mediated by PI3K/AKT/mTOR pathway].
Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi
January 2025
Department of Neurosurgery, Wuhan NO.1 Hospital, Wuhan 432000, China. *Corresponding author, E-mail:
Objective To investigate the effects and molecular mechanism of Homer protein homolog 1a (Homer 1a) overexpression on nerve injury in mice with traumatic brain injury (TBI). Methods Sixty male C57BL/6 mice were randomly divided into five groups: sham group, TBI group, empty lentivirus (Lv-NC) group, Homer 1a overexpression lentivirus (Lv-Homer 1a) group and Lv-Homer 1a + 740 Y-P group, with 12 mice in each group. The lentivirus was orthotopic injected into the cerebral cortex of mice 5 d before modeling, while 740 Y-P was injected intraperitoneally 1 d before modeling.
View Article and Find Full Text PDFStructural and Photoluminescent Investigation of Eu Doped Ca(PO)Cl Chloropatite Phosphor by Modified Pechini Method: Crystal Structure and Judd-ofelt Description of Radiative Properties.
J Fluoresc
January 2025
Department of Physics, R. T. M. Nagpur University, 440033, Nagpur, India.
The preparation of new phosphor with outstanding luminescent properties for white light-emitting diodes (WLEDs) is consistently a challenging. Here in the present study, A novel white-emitting chloropatite phosphor Ca(PO)Cl:Eu was synthesized via the pechini sol gel synthesis with citric acid and polyethylene glycol (PEG) acid as a fuel at 850 °C systematically investigating the impact of doping concentration and synthesis temperature on both photoluminescence properties and crystal phase. The structural characteristics and crystalline nature of the prepared sample were investigated by using X-ray diffraction (XRD) patterns and Fourier transform infrared (FT-IR) spectra.
View Article and Find Full Text PDFAutophagy related 7 (ATG7) regulates food intake and liver health during asparaginase exposure.
J Biol Chem
January 2025
Nutritional Sciences Graduate Program, Rutgers University, New Brunswick, New Jersey, United States; Rutgers Cancer Institute of New Jersey, New Brunswick, New Jersey, United States; Department of Nutritional Sciences, Rutgers University, New Brunswick, New Jersey, United States; Endocrinology and Animal Biosciences Graduate Program, Rutgers University, New Brunswick, New Jersey, United States; New Jersey Institute for Food, Nutrition and Health, Rutgers University, New Brunswick, New Jersey, United States. Electronic address:
Amino acid starvation by the chemotherapy agent asparaginase is a potent activator of the integrated stress response (ISR) in liver and can upregulate autophagy in some cell types. We hypothesized that autophagy related 7 (ATG7), a protein that is essential for autophagy and an ISR target gene, was necessary during exposure to asparaginase to maintain liver health. We knocked down Atg7 systemically (Atg7) or in hepatocytes only (ls-Atg7KO) in mice before exposure to pegylated asparaginase for 5 d.
View Article and Find Full Text PDFInvestigation of Spectroscopic Parameters and Trap Parameters of Eu-Activated YSiO Phosphors for Display and Dosimetry Applications.
Molecules
December 2024
Department of Science and Humanities, School of Engineering and Technology, CHRIST University, Bangalore 560029, Karnataka, India.
Using the solid-state reaction technique, varied YSiO phosphors activated by europium (Eu) ions at varied concentrations were made at calcination temperatures of 1000 °C and 1250 °C during sintering in an air environment. The XRD technique identified the monoclinic structure, and the FTIR technique was used to analyze the generated phosphors. Photoluminescence emission and excitation patterns were measured using varying concentrations of Eu ions.
View Article and Find Full Text PDFEffect of Eight Months of Swimming on Bone Quality of Different Anatomical Regions: A Study on Wistar Rat Models.
Calcif Tissue Int
January 2025
Research Centre in Physical Activity, Health and Leisure (CIAFEL), Faculty of Sport, University of Porto, (FADEUP), Rua Dr. Plácido Costa 91, 4200-450, Porto, Portugal.
Swimming is a popular sport with several health benefits, but its effects on bone quality are controversial possibly due to distinct effects on different anatomical regions. Our aim was to investigate the effect of 8-month swimming on bone growth, mass, geometry, trabecular microarchitecture and osteocyte density of the lumbar vertebrae, femur and tibia of male rats. Wistar rat models were assigned to either a swimming (n = 10; 2h/d, 5 d/week) or a physically active control group (n = 10) for 8 months, after which they were sacrificed and their lumbar vertebrae, femur and tibia assessed for bone mass, cortical geometry, trabecular microarchitecture and osteocyte density through µ-CT and histology.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!