AI Article Synopsis
- Soluble CD30 (sCD30) is a potential biomarker for monitoring the activated immune response in transplant patients, specifically in relation to acute rejection of allografts.
- This meta-analysis reviewed 18 studies involving 1,453 patients from various electronic databases to assess the relationship between post-transplant sCD30 levels and acute rejection at different time points.
- Results indicated a strong association between elevated sCD30 levels and acute kidney rejection across all time intervals post-transplant, with deceased donor transplants showing a higher correlation to increased sCD30 levels compared to living donor transplants.
Article Abstract
Soluble CD30 (sCD30) is considered to be a marker for the activated immune system in which T cells can damage the allograft. Some studies reported that post-transplant sCD30 can predict early acute rejection and can thereby be used as a biomarker to detect acute rejection. However, several other studies found no relation between post-transplant sCD30 and acute rejection. This meta-analysis study aims to answer this main question of whether sCD30 can help clinicians to monitor transplant recipients. The electronic databases, including PubMed, Web of Science, ProQuest, Embase, Scopus, Google Scholar, the gray literature, and the key journals, were searched for observational studies from 1 January 1990 up to 30 April 2018. Eighteen studies, with a total of 1,453 patients, were included in this paper. With regard to the different measurement times, post-transplant sCD30 was separately analyzed and divided into five groups (i.e., 1, 2, 3, 4 week, and 1 month post-transplant sCD30). All groups indicated a strong association between sCD30 and the acute rejection. The standardized mean difference (SMD) is 1.22 in 1 week, 0.77 in 2 week, 1.11 in 3 week, 1.27 in 4 week, and 0.71 in 1 month groups. The association between sCD30 and acute rejection was consistent across all the subgroup analyses. We found that post-transplant sCD30 had a strong association with acute kidney rejection. We also found that the deceased donors had more association with the high amount of sCD30 than living donors in patients with acute rejection. Finally, we realized that donor type was an important factor leading to the heterogeneous results in the primary studies.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7093023 | PMC |
| http://dx.doi.org/10.3389/fimmu.2020.00295 | DOI Listing |
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