AI Article Synopsis
- 3D bioprinting typically produces static biomedical materials that can't adapt to changes in the body's environment.
- The introduction of 4D printing allows for materials that can change shape or function when exposed to specific stimuli, enhancing adaptability in biomedical applications.
- The review covers current and potential uses of 4D printing in areas like tissue engineering and drug delivery, while also addressing limitations and future research directions.
Article Abstract
Most of the biomedical materials printed using 3D bioprinting are static and are unable to alter/transform with dynamic changes in the internal environment of the body. The emergence of four-dimensional (4D) printing addresses this problem. By preprogramming dynamic polymer materials and their nanocomposites, 4D printing is able to produce the desired shapes or transform functions under specific conditions or stimuli to better adapt to the surrounding environment. In this review, the current and potential applications of 4D-printed materials are introduced in different aspects of the biomedical field, e.g., tissue engineering, drug delivery, and sensors. In addition, the existing limitations and possible solutions are discussed. Finally, the current limitations of 4D-printed materials along with their future perspective are presented to provide a basis for future research.
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| http://dx.doi.org/10.1021/acs.jmedchem.9b02115 | DOI Listing |
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