Sulfur dioxide (SO) derivatives play critical roles in various biological processes. Therefore, effective methods for monitoring SO are of vital importance in bisulfite/sulfite biology. In this study, a two-photon (TP) imaging probe (CQ-SO) for detecting SO derivatives was designed and constructed, based on the chromenoquinoline (CQ) fluorophore and a β-chlorovinyl aldehyde sensing moiety. The TP properties of the CQ derivatives were revealed for the first time in this study. This study enriched the biological application range of CQ derivatives and also provided a new choice for the development of TP dyes. In particular, the CQ-SO probe exhibited a fast response time (about 5 s), low detection limit (16 nM) and ultrahigh specificity towards SO derivatives. Furthermore, the probe was successfully applied to the highly specific TP bioimaging of SO derivatives in living cells and zebrafish.
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