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Injectable amine functionalized graphene and chondroitin sulfate hydrogel with potential for cartilage regeneration. | LitMetric

AI Article Synopsis

  • Damaged cartilage often requires surgery but shows limited improvement in recovery; therefore, a new synthetic material for treatment is being explored.
  • Researchers used Johnson-Claisen rearrangement chemistry on graphene oxide to create a bioactive hydrogel (EDAG-CS) that helps promote cartilage regeneration through stem cell differentiation.
  • The EDAG-CS hydrogel forms quickly, has enhanced mechanical properties, is highly porous, and supports human stem cell growth, presenting a promising option for better healing of cartilage lesions.

Article Abstract

Damaged cartilage does not readily heal and often requires surgical intervention that only modestly improves outcomes. A synthetic material that could be injected and covalently crosslinked in situ to form a bioactive, mechanically robust scaffold that promotes stem cell chondrogenic differentiation holds promise for next-generation treatment of cartilage lesions. Here, Johnson-Claisen rearrangement chemistry was performed on graphene oxide (GO) to enable functionalization with a primary amine covalently bound to the graphenic backbone through a chemically stable linker. The primary amines are used to form covalent crosslinks with chondroitin sulfate, an important component of cartilage that promotes regeneration, to form a hydrogel (EDAG-CS). The EDAG-CS system gels in situ within 10 min, and the graphenic component imparts improved mechanical properties, including stiffness (320% increase) and toughness (70% increase). EDAG-CS hydrogels are highly porous, resistant to degradation, and enable the growth of human mesenchymal stem cells and their deposition of collagen matrix. This system has potential to improve clinical outcomes of patients with cartilage damage.

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Source
http://dx.doi.org/10.1039/c8tb02967aDOI Listing

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