Self-assembly is a bottom-up strategy that can be used to construct a wide range of nanostructures. This review discusses the applications of self-assembled nanomaterials in the field of antitumour therapy. A variety of materials have been developed, such as nanomaterials self-assembled from polymers, biomacromolecules, proteins, peptides, inorganic materials, nucleic acids, and organic molecules, among others, and their applications include phototherapy, chemotherapy, gene therapy, imaging, immunotherapy and other fields. These therapeutic methods can combine with each other as synergistic therapy. Here, we review the progress of self-assembled anticancer nanomaterials applied to target tumours, decrease drug resistance, cross the blood-brain barrier to treat metastases, and perform other tasks. Additional challenges to be overcome in this field are also discussed.
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http://dx.doi.org/10.1039/c8tb01978a | DOI Listing |
ACS Nano
January 2025
Conte Center for Polymer Research, Polymer Science and Engineering, University of Massachusetts Amherst, Amherst, Massachusetts 01003, United States.
Bottlebrush block copolymers (BBCPs) are a unique class of materials that contain a backbone with densely grafted and chemically distinct polymeric side chains. The nonlinear architecture of BBCPs provides numerous degrees of freedom in their preparation, including control over key parameters such as grafting density, side chain length, block arrangement, and overall molecular weight. This uniquely branched structure provides BBCPs with several important distinctions from their linear counterparts, including sterically induced side chain and backbone conformations, rapid and large self-assembled nanostructures, and reduced or eliminated entanglement effects (assuming sufficient grafting density and that the molecular weight of the side chains is below their respective entanglement molecular weight).
View Article and Find Full Text PDFFront Immunol
January 2025
Institute of Biopharmaceutical and Health Engineering, Tsinghua Shenzhen International Graduate School, Tsinghua University, Shenzhen, China.
Background: Epstein-Barr virus (EBV) is a significant global public health concern because of its association with various malignancies and autoimmune diseases. Over 90% of the global population is chronically infected with EBV, impacting numerous cancer-related cases annually. However, none of the effective prophylactic vaccines against EBV is approved at present.
View Article and Find Full Text PDFAdv Mater
January 2025
State Key Laboratory of Precision and Intelligent Chemistry, University of Science and Technology of China, Hefei, Anhui, 230026, China.
Currently, there is no conclusive evidence indicating that in situ self-assembled Gd nanostructures of varying sizes demonstrate distinct T and T signal enhancement capabilities. Furthermore, it remains uncertain whether size adjustment can effectively achieve enhanced T-T dual-modal MRI. To address these uncertainties, a two-step in situ self-assembly strategy is developed.
View Article and Find Full Text PDFJ Phys Chem C Nanomater Interfaces
January 2025
Furman University, Greenville, South Carolina 29613, United States.
Surface-anchored metal-organic frameworks (surMOFs) are crystalline, nanoporous, supramolecular materials mounted to substrates that have the potential for integration within device architectures relevant for a variety of electronic, photonic, sensing, and gas storage applications. This research investigates the thin film formation of the Cu-BDC (copper benzene-1,4-dicarboxylate) MOF system on a carboxylic acid-terminated self-assembled monolayer by alternating deposition of solution-phase inorganic and organic precursors. X-ray diffraction (XRD) and atomic force microscopy (AFM) characterization demonstrate that crystalline Cu-BDC thin films are formed via Volmer-Weber growth.
View Article and Find Full Text PDFInt J Mol Sci
December 2024
Department of Chemistry, Hanyang University, 222 Wangsimni-ro, Seongdong-gu, Seoul 04763, Republic of Korea.
The effect of solution pH on the formation and surface structure of 2-pyrazinethiolate (2-PyzS) self-assembled monolayers (SAMs) formed by the adsorption of 2-mercaptopyrazine (2-PyzSH) on Au(111) was investigated using scanning tunneling microscopy (STM) and X-ray photoelectron microscopy (XPS). Molecular-scale STM observations clearly revealed that 2-PyzS SAMs at pH 2 had a short-range ordered phase of (2√3 × √21)R30° structure with a standing-up adsorption structure. However, 2-PyzS SAMs at pH 8 had a very unique long-range ordered phase, showing a "ladder-like molecular arrangement" with bright repeating rows.
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