AI Article Synopsis
- Photodynamic therapy (PDT) is effective for cancer treatment but faces challenges like tumor hypoxia and tracking methods.
- Researchers developed a nanocomplex (BCSM NPs) using bovine serum albumin, which acts as a photosensitizer carrier and helps increase oxygen levels in tumors.
- In vivo tests in mice showed that BCSM NPs significantly reduced tumor growth compared to traditional methods, indicating their potential for improving PDT and enabling better imaging techniques.
Article Abstract
Photodynamic therapy (PDT) has been widely applied in cancer treatment due to minimal invasion, negligible side effects and specific tumor ablation. However, the treatment efficiency has been hindered by hypoxia in solid tumors, hydrophobic photosensitizers and their real time tracking. In this paper, we constructed an intelligent and biocompatible bovine serum albumin (BSA)-Ce6-Si QDs-MnO (BCSM NPs) nanocomplex as a pH/HO responsive photosensitizer nanocarrier to modulate tumor hypoxia for fluorescence imaging-guided efficient PDT. This versatile nanosystem not only enhanced the loading capacity of the photosensitizer and the formation of cytotoxic singlet oxygen (O) owing to the intelligent production of oxygen catalyzed by MnO from the endogenous HO, but also performed as a dual functional fluorescence and Magnetic Resonance imaging (MRI) probe. In vivo experiments in nude mice further confirmed that BCSM NPs significantly inhibited the growth of HeLa bearing-tumors compared to free Ce6. The results highlight the great potentail of multifunctional BCSM NPs for in vivo imaging as well as enhancing the photodynamic therapy efficiency.
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| http://dx.doi.org/10.1039/c8tb00931g | DOI Listing |
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