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An atlas of the shared genetic architecture between atopic and gastrointestinal diseases.
Commun Biol
December 2024
Department of Gastroenterology, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, Guangdong, China.
Comorbidity among atopic diseases (ADs) and gastrointestinal diseases (GIDs) has been repeatedly demonstrated by epidemiological studies, whereas the shared genetic liability remains largely unknown. Here we establish an atlas of the shared genetic architecture between 10 ADs or related traits and 11 GIDs, comprehensively investigating the comorbidity-associated genomic regions, cell types, genes and genetically predicted causality. Although distinct genetic correlations between AD-GID are observed, including 14 genome-wide and 28 regional correlations, genetic factors of Crohn's disease (CD), ulcerative colitis (UC), celiac disease and asthma subtypes are converged on CD4 T cells consistently across relevant tissues.
View Article and Find Full Text PDFMulti-ancestry genome-wide association study reveals novel genetic signals for lung function decline.
medRxiv
November 2024
RTI International, Research Triangle Park, NC.
Article Synopsis
- Accelerated decline in lung function is linked to chronic respiratory diseases, and while genetics play a role, few genetic connections have been found.
- This study aimed to investigate genetic variants associated with lung function decline using genome-wide association studies (GWAS) across diverse populations in multiple cohorts.
- They identified 361 significant genetic variants potentially related to lung function declines, with some replicated in additional cohorts, indicating strong genetic influences on respiratory health.
Roflumilast and cognition enhancement: A translational perspective.
Biomed Pharmacother
December 2024
Department of Neuropsychology and Psychopharmacology, Maastricht University, Netherlands. Electronic address:
Cognitive impairment affiliated with neurological disorders has a severe impact on daily life functioning and the quality of life of patients. This is associated with a significant and long-lasting health, social and financial burden, not only for the patients, but also for families and the wider society. However, treatment for cognitive impairment is only available for the indication Alzheimer's disease (AD) and its prodromal stage Mild Cognitive Impairment (MCI), although with major adverse effects, i.
View Article and Find Full Text PDFFormoterol dynamically alters endocannabinoid tone in the periaqueductal gray inducing headache.
J Headache Pain
November 2024
Department of Pharmacology, College of Medicine, University of Arizona, Tucson, AZ, United States.
Background: Headache is a pain disorder present in populations world-wide with a higher incidence in females. Specifically, the incidences of medication overuse headache (MOH) have increased worldwide. Comorbidities of MOH include photosensitivity, anxiety, "brain fog", and decreased physical activity.
View Article and Find Full Text PDFDoxifluridine effectively kills antibiotic-resistant in chronic obstructive pulmonary disease.
Microbiol Spectr
November 2024
Department of Respiratory, The Affiliated Hospital of Jiaxing University, Jiaxing, Zhejiang, China.
Chronic obstructive pulmonary disease (COPD) is a leading cause of morbidity and mortality globally, often exacerbated by infections such as methicillin-resistant (MRSA). The rise in antibiotic-resistant strains complicates treatment and underscores the need for novel therapeutic drugs. In this paper, we further investigated the antimicrobial potential of a fluoropyrimidine anticancer drug doxifluridine against multidrug-resistant .
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