Polymer biointerfaces are considered suitable materials for the improvement and development of numerous applications [...].
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http://dx.doi.org/10.3390/polym12040793 | DOI Listing |
Biomacromolecules
December 2024
Laboratory for Macromolecular and Organic Chemistry, Department of Chemical Sciences, University of Padova, Padova 35131, Italy.
Cyclic poly(2-methyl-2-oxazine) (-PMOZI) brush shells on Au nanoparticles (NPs) exhibit enhanced stealth properties toward serum and different cell lines compared to their linear PMOZI (-PMOZI) counterparts. While selectively recruiting immunoglobulins, -PMOZI shells reduce overall human serum (HS) protein binding and alter the processing of complement factor 3 (C3) compared to chemically identical linear shells. Polymer cyclization significantly decreases NP uptake by nonphagocytic cells and macrophages in both complement-deficient fetal bovine serum (FBS) and complement-expressing HS, indicating ineffective functional opsonization.
View Article and Find Full Text PDFColloids Surf B Biointerfaces
December 2024
Key Laboratory of Macromolecular Synthesis and Functionalization (Ministry of Education), Department of Polymer Science and Engineering, Zhejiang University, Hangzhou 310027, China; Center of Healthcare Materials, Shaoxing Institute, Zhejiang University, Shaoxing 312000, China. Electronic address:
Polymethacrylate and its derivatives are widely used in food industry and biomedical applications for their plasticity, biocompatibility and optical transparency. However, susceptibility to bacterial growth on their surfaces limits their applications. In this study, linear and branched polyethyleneimine (PEI) molecules were grafted onto poly(ethyl methacrylate) (PEMA) via aminolysis using a simple one-step method to enhance the antibacterial properties of PEMA films.
View Article and Find Full Text PDFAdv Healthc Mater
December 2024
John A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, MA, 02138, USA.
Both rigid plastics and soft hydrogels find ample applications in engineering and medicine but bear their own disadvantages that limit their broader applications. Bonding these mechanically dissimilar materials may resolve these limitations, preserve their advantages, and offer new opportunities as biointerfaces. Here, a robust adhesion strategy is proposed to integrate highly entangled tough hydrogels and diverse plastics with high interfacial adhesion energy and strength.
View Article and Find Full Text PDFACS Appl Mater Interfaces
December 2024
Beijing National Laboratory for Molecular Sciences (BNLMS), CAS Research/Education Center for Excellence in Molecular Sciences, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, P. R. China.
Silver, as the oldest antibacterial material, has been almost replaced by other alternatives for its insufficient activity or potential side-effects on the ecosystem due to the over-release of Ag ions (Ag). Herein, a facile and general strategy is developed to on-substrate fabricate silver coordination polymer nanowire arrays (Ag CPN) by simply immersing Ag-containing substrates into cationic surfactant solution at room temperature. Such a Ag CPN not only provides high-surface-area nano-biointerfaces for destroying microorganisms via physicomechanical interactions but also acts as a safe Ag reservoir, steadily releasing Ag at a relatively high but safe level (∼40 ppb, but lower than the safe level of 100 ppb).
View Article and Find Full Text PDFSmall
December 2024
Tissue Electronics, Istituto Italiano di Tecnologia, Naples, 80125, Italy.
The integration of organic electronic materials with biological systems to monitor, interface with, and regulate physiological processes is a key area in the field of bioelectronics. Central to this advancement is the development of cell-chip coupling, where materials engineering plays a critical role in enhancing biointerfacing capabilities. Conductive polymers have proven particularly useful in cell interfacing applications due to their favorable biophysical and chemical properties.
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