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http://dx.doi.org/10.1038/s41419-020-2373-8 | DOI Listing |
Front Immunol
November 2023
Herman B Wells Center for Pediatric Research, Department of Pediatrics, Indiana School of Medicine, Indianapolis, IN, United States.
[This corrects the article DOI: 10.3389/fimmu.2023.
View Article and Find Full Text PDFEur J Prev Cardiol
January 2024
Hospital del Mar Research Institute (IMIM), Programme of Epidemiology and Public Health, Dr Aiguader, 88, 08003 Barcelona, Spain.
Aims: Diet quality might influence cardiometabolic health through epigenetic changes, but this has been little investigated in adults. Our aims were to identify cytosine-phosphate-guanine (CpG) dinucleotides associated with diet quality by conducting an epigenome-wide association study (EWAS) based on blood DNA methylation (DNAm) and to assess how diet-related CpGs associate with inherited susceptibility to cardiometabolic traits: body mass index (BMI), systolic blood pressure (SBP), triglycerides, type 2 diabetes (T2D), and coronary heart disease (CHD).
Methods And Results: Meta-EWAS including 5274 participants in four cohorts from Spain, the USA, and the UK.
Genome Med
October 2021
The State Key Laboratory of Pharmaceutical Biotechnology, Department of Hematology, the Affiliated Drum Tower Hospital of Nanjing University Medical School, China-Australia Institute of Translational Medicine, School of Life Sciences, Nanjing University, 163 Xianlin Avenue, Nanjing, 210023, China.
Adv Immunol
October 2021
Institut de recherches cliniques de Montréal-IRCM, Montréal, QC, Canada; Département de microbiologie, infectiologie et immunologie, Université de Montréal, Montréal, QC, Canada; Division of Experimental Medicine, McGill University, Montréal, QC, Canada. Electronic address:
GFI1 and GFI1B are small nuclear proteins of 45 and 37kDa, respectively, that have a simple two-domain structure: The first consists of a group of six c-terminal CH zinc finger motifs that are almost identical in sequence and bind to very similar, specific DNA sites. The second is an N-terminal 20 amino acid SNAG domain that can bind to the pocket of the histone demethylase KDM1A (LSD1) near its active site. When bound to DNA, both proteins act as bridging factors that bring LSD1 and associated proteins into the vicinity of methylated substrates, in particular histone H3 or TP53.
View Article and Find Full Text PDFCell Death Dis
March 2020
Department of Molecular Cell Biology, Sungkyunkwan University, Suwon, Republic of Korea.
A correction to this paper has been published and can be accessed via a link at the top of the paper.
View Article and Find Full Text PDFEnter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!