Adrenocortical carcinomas are devastating cancers, expressing high levels of glutathione peroxidase 4 (GPX4). Therefore, it was recently suggested that these tumors might be therapeutically targeted by inducing ferroptosis. In this issue of , Weigand et al. describe the organ-specific production of steroid hormones as a potential culprit for the exquisite sensitivity of these cancers to ferroptosis.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7136258PMC
http://dx.doi.org/10.1038/s41419-020-2433-0DOI Listing

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