AI Article Synopsis
- Dendritic spines are small structures on neuron dendrites that play a crucial role in synaptic connections and are important for learning and memory.
- The structural changes of these spines, known as structural plasticity, are influenced by complex biochemical signals that occur on different levels and timescales.
- The review discusses various methods used to study and understand the molecular mechanisms of these changes in dendritic spines, with the goal of uncovering how they contribute to learning and memory in animals.
Article Abstract
Dendritic spines are tiny protrusions emanating from the neuronal dendrites, typically housing single excitatory postsynapses. Structural plasticity of dendritic spines is considered to be essential for synaptic functional plasticity and also reorganization of neural circuits during learning and memory. Structural plasticity of spines is mediated by complex biochemical signaling with various spatial and temporal scales. A variety of methods based on pharmacological, genetic, molecular, imaging and optical approaches has been developed and applied to dissect the complex signal transduction pathways. In this review, we overview both conventional and new methodological approaches to identify, monitor and manipulate key molecules for structural plasticity of dendritic spines, ultimately aiming to understand the molecular mechanism of learning and memory in behaving animals.
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| http://dx.doi.org/10.1111/ejn.14734 | DOI Listing |
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