Mannosylerythritol lipids (MELs) are novel biosurfactants performing excellent physical-chemical properties as well as bioactivities. This study is aimed to explore the antibacterial and antibiofilm activity of mannosylerythritol lipids against foodborne gram-positive Staphylococcus aureus. The results of growth curve and survival rate revealed the significant inhibitory effect of MELs against S. aureus. The visualized pictures by scanning electron microscope and transmission electron microscope exposed apparent morphological and ultrastructure changes of MEL-treated cells. Furthermore, flow cytometry confirmed that MELs have promoted cell apoptosis and damaged the cell membrane. Notably, MEL-A also exhibited outstanding antibiofilm activity against S. aureus biofilm on different material surfaces including polystyrene, glass, and stainless steel, verified by confocal laser scanning microscope. These findings suggest that the antimicrobial activity of MELs is related to inhibit planktonic cells and biofilm of S. aureus, indicating that it has potential to be an alternative to antibacterial agents and preservatives applied into food processing.Key Points • MELs have strong antibacterial activity against Staphylococcus aureus.• MELs mainly damage the cell membrane of Staphylococcus aureus.• Mannosylerythritol lipids inhibit the bacterial adhesion to remove biofilm.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1007/s00253-020-10561-8 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Glycolipid and Lipopeptide Biosurfactants: Structural Classes and Characterization-Rhamnolipids as a Model.
Crit Rev Anal Chem
December 2024
Institut de Chimie Organique et Analytique, ICOA, UMR 7311 Université d'Orléans - Pôle de chimie, Orléans Cedex 2, France.
In recent years, biosurfactants (BS) produced by various bacteria, fungi and yeast strains have attracted much interest because of their unique properties and potential applications in many industries ranging from bioremediation to agriculture and biomedical to cosmetics. Glycolipids are a popular group of BS that include rhamnolipids, sophorolipids, mannosylerythritol, trehalose lipids, xylolipids and cellobiose lipids. Lipopeptides e.
View Article and Find Full Text PDFEnhancement of mono-acylated MEL-D production in an acyltransferase gene-deleted strain of by supplementation with di-acylated MEL-B in culture medium.
Heliyon
November 2024
Research Institute for Sustainable Chemistry, National Institute of Advanced Industrial Science and Technology (AIST), Tsukuba Central 5-2, 1-1-1 Higashi, Tsukuba, Ibaraki, 305-8565, Japan.
Mannosylerythritol lipids (MELs) are glycolipid biosurfactants produced by various yeasts. MEL producers produce mainly di-acylated MELs (consisting of two fatty acid chains). Among them, is a di-acylated MEL-B (d-MEL-B) producer.
View Article and Find Full Text PDFEnhancement of mannosylerythritol lipid-A on physicochemical stability, antioxidant activity, and bioavailability of bovine lactoferrin emulsion under different pH conditions.
Int J Biol Macromol
December 2024
College of Food Engineering and Nutritional Science, Shaanxi Normal University, Xi'an 710119, Shaanxi, China. Electronic address:
This study systematically explored the enhancement of mannosylerythritol lipid-A (MEL-A) on physicochemical stability, antioxidant activity, and bioavailability of bovine lactoferrin (BLF) emulsion under different pH conditions by spectroscopic techniques, molecular simulation, and simulated in vitro digestion model. The bovine lactoferrin-MEL-A (BLF-MEL-A) emulsions were prepared and characterized with the Fourier infrared, of which results showed that high concentration MEL-A (1.00 mg/mL) changed the secondary structure of pH-induced BLF and rendered an increase in β-sheet and random coil fractions.
View Article and Find Full Text PDFThe dual role of mannosylerythritol lipid-A: Improving gelling property and exerting antibacterial activity in chicken and beef gel.
Food Chem
February 2025
College of Food Engineering and Nutritional Science, Shaanxi Normal University, Xi'an 710119, Shaanxi, China. Electronic address:
Gel meat products are important in the meat market. To develop high-quality meat gel products, mannosylerythritol lipid-A (MEL-A) was added to chicken and beef gels, and their physicochemical and biological properties of the composite gel formed by heating were determined in this study. The results of texture analysis showed that MEL-A could significantly improve the hardness, gumminess and chewiness of meat gels and reduce water loss (P < 0.
View Article and Find Full Text PDFBerberine-loaded mannosylerythritol lipid-B nanomicelles as drug delivery carriers for the treatment of Helicobacter pylori biofilms in vivo.
Eur J Pharm Biopharm
October 2023
College of Marine Life Sciences, Ocean University of China, No.5 Yushan Road, 266003, Qingdao, China. Electronic address:
Eradication of Helicobacter pylori biofilm is crucial to the treatment of H. pylori infections, especially regarding the challenge of fast development of antibiotic resistance in H. pylori worldwide.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!