AI Article Synopsis
- Tuberculosis (TB) is a significant global health issue, primarily due to rising drug-resistant cases, making early, effective treatment essential.
- Reliable point-of-care diagnostic methods are crucial for managing TB effectively, with common techniques including clinical assessments, microscopy, and culture, alongside newer molecular methods like GeneXpert and whole genome sequencing.
- This review focuses on various diagnostic strategies, from traditional methods to advanced next-generation sequencing, aimed at detecting Mycobacterium tuberculosis and resistance mutations in a clinical context.
Article Abstract
Tuberculosis (TB) is a major cause of deaths by a single infectious agent and has now been a global public health problem due to increasing numbers of drug-resistant cases. Early and effective treatment is crucial to prevent the emergence of drug-resistance strains. This demands the availability of fast and reliable point-of-care (POC) diagnostic methods for effective case management. Commonly used methods to screen and diagnose TB are clinical, immunological, microscopy, radiography, and bacterial culture. In addition, recent advances in molecular diagnostic methods including MTBDRplus, loop-mediated isothermal amplification (LAMP), line probe assay (LPA), GeneXpert, and whole genome sequencing (WGS) have been employed to diagnose and characterize TB. These methods can simultaneously identify Mycobacterium tuberculosis (MTB) and mutation(s) associated with routinely used anti-TB drugs. Here, we review the use of currently available diagnostic methods and strategies including conventional to recently implemented next-generation sequencing (NGS) methods used to detect MTB in clinical perspective.
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| http://dx.doi.org/10.1007/s11033-020-05413-7 | DOI Listing |
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