AI Article Synopsis
- Researchers isolated two new compounds (1 and 2) from the medicinal plant Dendrobium nobile, along with two new bisbibenzyl derivatives (3 and 4), and identified four known compounds (5-8).
- The structures of the new compounds 1 and 4 were determined using advanced NMR and ECD spectroscopy techniques.
- While the new compounds did not show antimicrobial effects against various bacteria, they displayed significant cytotoxicity towards HepG2 liver cancer cells, with IC values between 1.25 μM and 19.47 μM.
Article Abstract
Two new dihydrophenanthrofurans (1 and 2) and two new bisbibenzyl derivatives (3 and 4) were isolated from the traditional Chinese medicinal plant Dendrobium nobile, along with four known compounds (5-8). The absolute configurations of compounds 1 and 4 were elucidated through extensive NMR and ECD spectroscopic analyses. New compounds showed no antimicrobial activity against four gram-positive bacterial strains and four gram-negative bacteria at the concentration of 1 mg/mL, but displayed significant cytotoxic activity against HepG2 human hepatic cell line with the IC values ranging from 1.25 μM to 19.47 μM.
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| http://dx.doi.org/10.1016/j.fitote.2020.104586 | DOI Listing |
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