AI Article Synopsis
- Dietary prebiotics are substances that can be broken down by various gut microorganisms, producing short-chain fatty acids (SCFAs) that impact the host's physiological functions.
- Current research focuses on how these prebiotics and their metabolic byproducts interact with cellular signaling pathways and influence gene expression through epigenetic mechanisms.
- This review aims to present a comprehensive understanding of the latest concepts of prebiotics and their effects on both local and systemic health in humans.
Article Abstract
Dietary prebiotics can be metabolized by different colonic microorganisms and release several classes of metabolites, particularly SCFAs into the intestine lumen, influencing the host physiology. Thus, human microbiota has been the focus of one of the most dynamic research fields of our time and their efforts are directed to understand how prebiotics structures and the microbiota-derived metabolites acts on signaling cell pathways and epigenetic control. Therefore, the aim of this review is to provide an overview about the new concept of prebiotics and their mechanistic local and systemically insights related to the host health.
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| http://dx.doi.org/10.1016/j.foodres.2019.108973 | DOI Listing |
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