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Thermosensory behaviors of the free-living life stages of Strongyloides species support parasitism in tropical environments.
PLoS Negl Trop Dis
December 2024
Department of Neurobiology and Biophysics, University of Washington, Seattle, Washington, United States of America.
Soil-transmitted parasitic nematodes infect over 1 billion people worldwide and are a common source of neglected disease. Strongyloides stercoralis is a potentially fatal skin-penetrating human parasite that is endemic to tropical and subtropical regions around the world. The complex life cycle of Strongyloides species is unique among human-parasitic nematodes in that it includes a single free-living generation featuring soil-dwelling, bacterivorous adults whose progeny all develop into infective larvae.
View Article and Find Full Text PDF[Strongyloidiasis as a cause of multiorganic failure].
Medicina (B Aires)
December 2024
Hospital Municipal de Agudos Leónidas Lucero, Bahía Blanca, Buenos Aires, Argentina.
Strongyloides stercoralis is a parasite that has the ability to reproduce within humans, which explains its persistence for many years. It lives in the duodenum and ileum, between the enterocytes, and opens up to the intestinal lumen. Historically it is associated with tropical and subtropical rural areas, but its development has been seen in microclimates that favour the biological cycle.
View Article and Find Full Text PDFEvaluation of an Innovative Rapid Diagnostic Test for Human Strongyloidiasis to Detect Specific IgG Antibody in Whole-Blood Samples.
Am J Trop Med Hyg
December 2024
Department of Parasitology, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand.
Human strongyloidiasis is an important intestinal parasitic disease that affects public health globally and is transmitted through contact with infective larvae on contaminated soil. Immunocompromised hosts can experience hyperinfection, which can lead to fatal systemic strongyloidiasis. Here, an innovative point-of-care (POC) test kit, the strongyloidiasis immunochromatographic blood test (the NIE-SsIR whole-blood ICT) kit is described.
View Article and Find Full Text PDFChronic infection in Fijian migrants to the UK.
J Med Microbiol
November 2024
Department of Clinical Sciences, Liverpool School of Tropical Medicine, Liverpool, UK.
Article Synopsis
- - Human threadworm is a globally distributed parasite affecting over 600 million people, with serious implications for immunosuppressed individuals, yet its prevalence among Fijian migrants in the UK is largely unknown.
- - A study involving 250 Fijian migrants in the UK revealed a significant rate of gastrointestinal parasites (GIPs), with 35.1% testing positive for threadworm and 6.8% for hookworms, based on comprehensive diagnostic methods.
- - Findings emphasized the need for specialized parasitological testing, particularly multiplex real-time PCR (rtPCR), which proved more effective than traditional microscopy in diagnosing infections among chronic cases in this population.
Review of the WHO guideline on preventive chemotherapy for public health control of strongyloidiasis.
Lancet Infect Dis
October 2024
Department of Control of Neglected Tropical Diseases, WHO, Geneva, Switzerland.
Article Synopsis
- Strongyloidiasis is a widespread parasitic infection affecting 300-600 million people, particularly in tropical regions, and poses serious health risks, especially during immunosuppression, with high fatality rates.
- There have been no significant global health initiatives targeting this disease until recently, when the WHO included it in their roadmap for controlling neglected tropical diseases, highlighting its importance.
- The new WHO guidelines recommend mass drug administration of ivermectin in areas with a prevalence of over 5%, aiming for effective public health strategies to combat strongyloidiasis.
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