In rats, intramuscular injection of oxytocin (0.25 nmol/100 g body weight) increased sodium excretion from 19±5 to 120±11 μmol/min. A significant correlation (p<0.001) was revealed between renal excretion of oxytocin and sodium ions. Under the action of oxytocin, natriuresis was characterized by diminished reabsorption of fluid in the proximal tubule of the nephron attested by elevated lithium clearance rate and from stimulation of V receptors in the cells of thick ascending loop of Henle. Pmp-Tyr(Me)-Phe-Gln-Asn-Cys-Pro-Arg-Gly-NH2, a V receptors antagonist, prevented the natriuretic effect of oxytocin.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1007/s10517-020-04768-y | DOI Listing |
Publication Analysis
Top Keywords
mechanism natriuretic
4
natriuretic oxytocin
4
oxytocin rats
4
rats intramuscular
4
intramuscular injection
4
injection oxytocin
4
oxytocin 025
4
025 nmol/100
4
nmol/100 body
4
body weight
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!