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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7185100 | PMC |
| http://dx.doi.org/10.18632/aging.103011 | DOI Listing |
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Article Synopsis
- SAV1 is a crucial tumor suppressor that activates the Hippo pathway, and its deficiency is linked to increased tumor growth and poor patient prognosis in various cancers.
- Treatment with the small molecule lycorine boosts SAV1 levels in lung cancer cells by preventing its degradation and activating MST1, which in turn reduces the oncogenic YAP protein and its associated signaling pathways.
- In experiments with tumor-bearing mice, lycorine not only elevated SAV1 levels but also significantly reduced tumor growth and metastasis, suggesting a potential new therapeutic approach for lung cancer targeting SAV1 deficiency.
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