Creating a Framework for Conducting Randomized Clinical Trials during Disease Outbreaks.

N Engl J Med

From the Department of Biostatistics, University of Florida, Gainesville (N.E.D., I.M.L.); the World Health Organization, Geneva (P.-S.G., A.M.H.-R.); the Department of Biostatistics, University of California, Los Angeles (R.B.); the Department of Biostatistics, Yale University, New Haven, CT (F.W.C.); the Department of Statistics (C.A.D.) and the Centre for Tropical Medicine and Global Health (P.H.), University of Oxford, Oxford, the Medical Research Council (MRC) Centre for Global Infectious Disease Analysis, Department of Infectious Disease Epidemiology, Imperial College London (C.A.D.), and the MRC Tropical Epidemiology Group, London School of Hygiene and Tropical Medicine (P.G.S.), London, and the Department of Mathematics and Statistics, Lancaster University, Lancaster (T.J.) - all in the United Kingdom; the Department of Biostatistics, Epidemiology, and Informatics, University of Pennsylvania, Philadelphia (S.S.E.); the Department of Biostatistics, University of Washington (T.R.F., M.E.H.), and the Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center (M.E.H.) - both in Seattle; the Office of Vaccines Research and Review, Center for Biologics Evaluation and Research, Food and Drug Administration, Silver Spring (P.R.K.), and the Biostatistics Research Branch, National Institute of Allergy and Infectious Diseases, Bethesda (M.C.N.) - both in Maryland; Institut National de Recherche Biomédicale, Kinshasa, Democratic Republic of Congo (S.M., J.-J.M.-T.); and the Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute (R.W.), and the Department of Biostatistics, Harvard T.H. Chan School of Public Health (R.W., V.D.G.) - both in Boston.

Published: April 2020

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7490833PMC
http://dx.doi.org/10.1056/NEJMsb1905390DOI Listing

Publication Analysis

Top Keywords

creating framework
4
framework conducting
4
conducting randomized
4
randomized clinical
4
clinical trials
4
trials disease
4
disease outbreaks
4
creating
1
conducting
1
randomized
1

Similar Publications

Secure IoT data dissemination with blockchain and transfer learning techniques.

Sci Rep

January 2025

Torrens University Australia, Fortitude Valley, QLD 4006, Leaders Institute, 76 Park Road, Woolloongabba, QLD 4102, Brisbane, Queensland, Australia.

In smart applications, streaming IoT data is essential to building trust in sustainable IoT solutions. However, most existing systems for storing and disseminating IoT data streams lack reliability, security, and transparency, primarily due to centralized architectures that create single points of failure. To address these limitations, this research introduces TraVel, a blockchain and transfer learning-based framework for secure IoT data management.

View Article and Find Full Text PDF

Biomimetic calcification is a micro-crystallization process that mimics the natural biomineralization process, where biomacromolecules regulate the formation of inorganic minerals. In this study, it is presented that a protein-assisted biomimetic calcification method for the in situ synthesis of nitrogen-doped metal-organic framework (MOF) materials. A series of unique core-shell structures are created by utilizing proteins as templates and guiding agents in the nucleation step, creating ideal conditions for shell growth.

View Article and Find Full Text PDF

Covalent organic frameworks (COFs), known for their exceptional in situ encapsulation and precise release capabilities, are emerging as pioneering drug delivery systems. This study introduces a hypoxia-responsive COF designed to encapsulate the chemotherapy drug gambogic acid (GA) in situ. Bimetallic gold-palladium islands were grown on UiO-66-NH (UiO) to form UiO@Au-Pd (UAPi), which were encapsulated with GA through COF membrane formation, resulting in a core-shell structure (UAPiGC).

View Article and Find Full Text PDF

Predictive Forwarding Rule Caching for Latency Reduction in Dynamic SDN.

Sensors (Basel)

December 2024

Department of Electrical Engineering & Computer Science, Daegu Gyeongbuk Institute of Science and Technology (DGIST), Daegu 42988, Republic of Korea.

In mission-critical environments such as industrial and military settings, the use of unmanned vehicles is on the rise. These scenarios typically involve a ground control system (GCS) and nodes such as unmanned ground vehicles (UGVs) and unmanned aerial vehicles (UAVs). The GCS and nodes exchange different types of information, including control data that direct unmanned vehicle movements and sensor data that capture real-world environmental conditions.

View Article and Find Full Text PDF

AllianceBlockchain in the Governance Innovation of Internet Hospitals.

Sensors (Basel)

December 2024

Department of Artificial Intelligence and Data Science, National University of Computer and Emerging Sciences, Islamabad 44000, Pakistan.

The rise of Internet hospitals has significant issues associated with data security and governance in managing sensitive patient data. This paper discusses an alliance blockchain (i.e.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!