AI Article Synopsis
- - A new method for a radical cross-coupling reaction uses visible light to combine diselenides or disulfides with -allylbromodifluoroacetamide without any catalyst.
- - This technique shows a strong ability to tolerate various functional groups and produces different types of 4-thio- and 4-seleno-substituted 3,3-difluoro-γ-lactams with moderate to good success rates.
- - Research suggests a possible mechanism for the reaction involving radical-radical interactions, supported by control experiments.
Article Abstract
A visible-light-induced, catalyst-free radical cross-coupling cyclization of diselenides or disulfides with -allylbromodifluoroacetamide has been developed. This developed protocol exhibits good functional group tolerance and affords a variety of 4-thio- and 4-seleno-substituted 3,3-difluoro-γ-lactams in moderate to good yields. Based on control experiments, a plausible radical-radical cross-coupling pathway is proposed.
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| http://dx.doi.org/10.1021/acs.joc.9b03490 | DOI Listing |
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