Aim: This study was undertaken to evaluate efficacy of Actovegin in the composition of comprehensive therapy in patients presenting with post-thrombotic disease of lower extremities free from trophic disorders.
Patients And Methods: The study included a total of 60 patients (28 men and 32 women) diagnosed as having post-thrombotic disease of lower limbs without trophic disorders (C1-C3 according to the CEAP classification), induced by previously endured iliofemoral phlebothrombosis. The duration of the disease varied from 1 year to 10 years. All patients for 10 days received Actovegin intravenously in drips at a dose of 1200 mg (30 ml of the drug reconstituted in 400 ml of normal saline) followed by continuing taking the drug orally in a daily dose of 1200 mg for 30 days. During the whole follow up period the patients wore class 2 compression stockings (RAL standard). The results of the carried out treatment in relation to the subjective complaints (pain, feeling of heaviness, convulsions, pruritus and paresthesias) were assessed by the visual analogue scale and based on the CIVIQ-20 questionnaire, with additionally measuring the malleolar circumference.
Results: On the background of the carried out therapy the patients demonstrated a significant decrease in the oedematous syndrome in the area of the ankles. This parameter decreased form 26.88±0.39 cm to 25.02±0.35 cm (p<0.05). The patients' complaints of tingling decreased form 5.73±0.79 to 2.32±0.68 points (p<0.05), the incidence and intensity of convulsions fell from 6.51±1.39 to 3.2±0.98 points (p<0.05). The intensity of the oedematous syndrome (swelling) decreased significantly from 8.11±1.75 to 4.33±1.20 points (p<0.05), the pain syndrome fell from 7.92±1.88 to 3.12±1.45 points (p<0.05), the feeling of heaviness in the lower limbs decreased from 8.52±1.73 to 3.91±1.48 points (p<0.05). Also, improvement of the general quality of life of patients was observed (the integral parameter decreased from 63.27±1.8 to 44.33±1.19 points, p<0.05).
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.33529/ANGIO2020115 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Expert-Based Narrative Review on Compression UltraSonography (CUS) for Diagnosis and Follow-Up of Deep Venous Thrombosis (DVT).
Diagnostics (Basel)
January 2025
Research Center on Thromboembolic Diseases and Antithrombotic Treatment, Department of Medicine and Surgery, University of Insubria, 21100 Varese, Italy.
Deep venous thrombosis (DVT) is a pathological condition that develops when a thrombus forms within the deep venous system. Typically, it involves the lower limbs and, less frequently, the upper extremities or other unusual districts such as cerebral or splanchnic veins. While leg DVT itself is rarely fatal and occasionally can lead to limb-threatening implications, its most fearsome complication, namely pulmonary embolism, is potentially fatal and significantly contributes to increased healthcare costs and impaired quality of life in affected patients and caregivers.
View Article and Find Full Text PDFPredictive Factors for Post-Thrombotic Syndrome in Patients with Deep Vein Thrombosis Treated with AngioJet Pharmacomechanical Thrombectomy: A Retrospective Single-Center Study.
Med Sci Monit
January 2025
Department of Vascular Surgery, The Second Affiliated Hospital of Nantong University, Nantong, Jiangsu, China.
BACKGROUND Deep venous thrombosis (DVT) is one of the most common peripheral vascular diseases. AngioJet pharmacomechanical thrombectomy has been widely used to treat DVT. This study evaluated outcomes of patients with DVT after pharmacomechanical thrombectomy and determined potential risk factors associated with prognosis.
View Article and Find Full Text PDF[RIGHT HEART FAILURE PRESENTATION OF IDIOPATHIC MASSIVE PULMONARY EMBOLISM - CASE REPORT].
Harefuah
December 2024
Internal Medicine F Department, Wolfson UMC Holon.
Massive pulmonary embolism (PE) is a life threatening condition with age-related escalation in prevalence. Acute PE is a common and sometimes fatal disease. The approach to the evaluation should be efficient while simultaneously avoiding the risks of unnecessary testing so that therapy can be promptly initiated and potential morbidity and mortality avoided.
View Article and Find Full Text PDFChronic venous disease of the lower limbs is a highly prevalent pathology and endovenous thermoablation is the technique of choice for treatment of insufficient saphenous veins. However, there is still controversy about the best management for varicose tributaries. This article reports a case of outpatient treatment of reflux of the small saphenous vein and tributary veins in a 52-year-old female patient with post-thrombotic syndrome complaining of pain and edema in the right lower limb.
View Article and Find Full Text PDFAssessing the Predictive Value of the Neutrophil-to-Lymphocyte Ratio for Post-Thrombotic Syndrome following Iliofemoral Deep Venous Thrombosis.
Ann Vasc Surg
November 2024
University of Maryland School of Medicine, Baltimore, MD; Division of Vascular Surgery, Department of Surgery, University of Maryland Medical Center, Baltimore, MD.
Article Synopsis
- Post-thrombotic syndrome (PTS) is a frequent complication following deep vein thrombosis (DVT), affecting 20-50% of patients and leading to a lower quality of life, with limited effective clinical predictors available for assessing PTS risk.
- A pilot study investigated the neutrophil-to-lymphocyte ratio (NLR), an indicator of systemic inflammation, as a potential predictive biomarker for PTS in patients diagnosed with iliofemoral DVT.
- The study found that an NLR cut-off of 7.71 could significantly predict PTS, with 36.44% of patients experiencing the syndrome, suggesting that NLR could be a useful tool in evaluating PTS risk alongside other clinical markers.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!