The noncovalent structural locking of thermoresponsive polyion complex micelles, nanowires, and vesicles can be implemented via hydrogen bonding assisted polyion complexation through polymerization-induced electrostatic self-assembly (PIESA) using an arginine-like cationic monomer.
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http://dx.doi.org/10.1039/d0cc00427h | DOI Listing |
Adv Colloid Interface Sci
January 2025
Department of Chemical and Materials Engineering, University of Alberta, Edmonton, Alberta T6G 1H9, Canada. Electronic address:
Biopolymers derived from natural resources are highly abundant, biodegradable, and biocompatible, making them promising candidates to replace non-renewable fossil fuels and mitigate environmental and health impacts. Nano-fibrous biopolymers possessing advantages of biopolymers entangle with each other through inter-/intra-molecular interactions, serving as ideal building blocks for gel construction. These biopolymer nanofibers often synergize with other nano-building blocks to enhance gels with desirable functions and eco-friendliness across various applications in biomedical, environmental, and energy sectors.
View Article and Find Full Text PDFCarbohydr Res
January 2025
Université Paris Cité and Université des Antilles and Université de la Réunion, INSERM, BIGR, F-75015 Paris, France. Electronic address:
Protein-carbohydrate interactions play a crucial role in numerous fundamental biological processes. Thus, description and comparison of the carbohydrate binding site (CBS) architecture is of great importance for understanding of the underlying biological mechanisms. However, traditional approaches for carbohydrate-binding protein analysis and annotation rely primarily on the sequence-based methods applied to specific protein classes.
View Article and Find Full Text PDFAngew Chem Int Ed Engl
January 2025
Nanjing University, State Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, CHINA.
Targeted degradation of membrane proteins represents an attractive strategy for eliminating pathogenesis-related proteins. Aptamer-based chimeras hold great promise as membrane protein degraders, however, their degradation efficacy is often hindered by the limited structural stability and the risk of off-target effects due to the non-covalent interaction with target proteins. We here report the first design of a covalent aptamer-based autophagosome-tethering chimera (CApTEC) for the enhanced autophagic degradation of cell-surface proteins, including transferrin receptor 1 (TfR1) and nucleolin (NCL).
View Article and Find Full Text PDFChemistry
January 2025
Institute of Chemical Research of Catalonia: Institut Catala d'Investigacio Quimica, -, Av. Països Catalans 16, 43007, Tarragona, SPAIN.
Noncovalent interactions are present in numerous synthetic and biological systems, playing an essential role in vital processes for life such as stabilization of proteins' structures or reversible binding in substrate-receptor complexes. Their study is relevant, but it presents challenges due to its inherent weak nature. In this context, molecular balances (MBs) are one of the most efficient physical organic chemistry tools to quantify noncovalent interactions, bringing beneficial knowledge regarding their nature and strength.
View Article and Find Full Text PDFACS Pharmacol Transl Sci
January 2025
Fraunhofer Institute for Translational Medicine and Pharmacology ITMP, Discovery Research ScreeningPort, Schnackenburgallee 114, 22525 Hamburg, Germany.
The SARS-CoV-2 papain-like protease PLpro has multiple roles in the viral replication cycle, related to both its polypeptide cleavage function and its ability to antagonize the host immune response. Targeting the PLpro function is recognized as a promising mechanism to modulate viral replication, while supporting host immune responses. However, the development of PLpro-specific inhibitors remains challenging.
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