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Diastolic blood pressure variability predicts adverse outcomes in stabilized acute heart failure patients.
Eur J Intern Med
March 2025
Department of Cardiology, Korea University Guro Hospital, Seoul, Republic of Korea.
Blood pressure variability; heart failure; Cardiovascular outcome; Diastolic blood pressure.
View Article and Find Full Text PDFFailure to recover from proactive semantic interference predicts trajectory of decline in everyday function among older adults with amnestic mild cognitive impairment.
Int Psychogeriatr
March 2025
Center for Cognitive Neuroscience and Aging, Department of Psychiatry and Behavioral Sciences, University of Miami Miller School of Medicine, Miami, FL 33136, United States; 1Florida Alzheimer's Disease Research Center, Gainesville, FL 32610, United States. Electronic address:
Objectives: To evaluate the predictive utility of proactive semantic interference (PSI) and failure to recover from proactive semantic interference (frPSI) deficits on the longitudinal everyday functional decline on the Clinical Dementia Rating Sum of Boxes (CDR-SOB) among older adults with amnestic mild cognitive impairment (aMCI).
Design: Longitudinal prospective cohort study.
Setting: 1Florida Alzheimer's Disease Research Center (1FLADRC).
Acute liver failure (ALF) is a severe, potentially reversible form of liver insufficiency, which is defined by the occurrence of hepatic coagulopathy and hepatic encephalopathy in patients with no previous hepatic disease. Acute liver failure is preceded by severe acute liver injury (ALI) with an increase in transaminases, jaundice, and deterioration in general condition over a period of hours to weeks. Every year 200-500 people develop ALF in Germany, most frequently on the background of toxic liver injury (e.
View Article and Find Full Text PDFInvestigating the impact of multidimensional sleep traits on cardiovascular diseases and the mediating role of depression.
Open Heart
March 2025
Department of Medical Statistics and Epidemiology, School of Public Health, Sun Yat-sen University, Guangzhou, China.
Background: Observational studies have reported that sleep is associated with the risk of major depressive disorder (MDD) and cardiovascular diseases (CVDs). However, the causal relationships among various sleep traits remain contentious, and whether MDD mediates the impact of specific sleep traits on CVDs is unclear.
Methods: We performed two-sample Mendelian randomisation analyses to explore whether insomnia, sleep time, daytime napping, daytime sleepiness, chronotype, snoring or obstructive sleep apnoea were causally associated with the risk of five CVDs, including coronary artery disease (CAD), myocardial infarction (MI), heart failure (HF), atrial fibrillation and stroke.
Toward improved clearance predictions and distribution profiles employing the isolated perfused rat liver model: Experimental optimization.
Drug Metab Dispos
January 2025
Drug Delivery and Disposition, Department of Pharmaceutical and Pharmacological Sciences, KU Leuven, Leuven, Belgium; BioNotus GCV, Niel, Belgium. Electronic address:
To reduce the drug attrition due to failure in clinical trials, an early accurate hepatic clearance (CL) prediction for small molecule drugs is critical. However, the routinely used in vitro to in vivo extrapolation (IVIVE) methods to predict human CL have led to significant underpredictions for many drug discovery programs. The ex vivo isolated perfused rat liver (IPRL) can be employed as a model to gain a mechanistic understanding of the root cause(s) of the frequent suboptimal performance of IVIVE methods.
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