Pregnane glycosides from the leaves of and their α-glucosidase and α-amylase inhibitory activities.

Three new pregnane glycosides, drevoluosides O-Q (-) along with five known volubiloside C (), dreageoside A11 (), 17-marsdenin (), stavaroside H (), and hoyacarnoside G () were isolated from the methanol extract of the leaves. Their structures were elucidated by chemical and spectroscopic methods. Compounds - showed significant anti -glucosidase activity with the inhibitory percentages ranging from 32.6 to 47.1% at the concentration of 200 μM. Compound showed significant inhibitory -amylase activity with IC value of 51.3 ± 2.1 μM.