A catastrophic bifurcation in non-linear dynamical systems, called crisis, often leads to their convergence to an undesirable non-chaotic state after some initial chaotic transients. Preventing such behavior has been quite challenging. We demonstrate that deep Reinforcement Learning (RL) is able to restore chaos in a transiently chaotic regime of the Lorenz system of equations. Without requiring any a priori knowledge of the underlying dynamics of the governing equations, the RL agent discovers an effective strategy for perturbing the parameters of the Lorenz system such that the chaotic trajectory is sustained. We analyze the agent's autonomous control-decisions and identify and implement a simple control-law that successfully restores chaos in the Lorenz system. Our results demonstrate the utility of using deep RL for controlling the occurrence of catastrophes in non-linear dynamical systems.
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http://dx.doi.org/10.1063/5.0002047 | DOI Listing |
J Clin Med
January 2025
Department of Trauma Surgery, Hannover Medical School, Carl-Neuberg-Str. 1, 30625 Hannover, Germany.
: Tactile gnosis derives from the interplay between the hand's tactile input and the memory systems of the brain. It is the prerequisite for complex hand functions. Impaired sensation leads to profound disability.
View Article and Find Full Text PDFJ Patient Exp
January 2025
Neo Q Quality in Imaging GmbH, Berlin, Germany.
Patient experience is a vital measure of healthcare quality, affecting satisfaction, engagement, and outcomes. Standardized radiology reporting can improve care by enhancing communication, reducing errors, and optimizing workflows. This article examines the role of structured reporting and AI in improving patient experience, addressing challenges like workload imbalances and communication issues.
View Article and Find Full Text PDFFront Immunol
January 2025
Institute for Immunodeficiency, Center for Chronic Immunodeficiency (CCI), Medical Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
Introduction: Human Cytotoxic-T-lymphocyte-antigen-4 (CTLA-4) insufficiency caused by heterozygous germline mutations in is a complex immune dysregulation and immunodeficiency syndrome presenting with reduced penetrance and variable disease expressivity, suggesting the presence of disease modifiers that trigger the disease onset and severity. Various genetic and non-genetic potential triggers have been analyzed in CTLA-4 insufficiency cohorts, however, none of them have revealed a clear association to the disease. Multiple HLA haplotypes have been positively or negatively associated with various autoimmune diseases and inborn errors of immunity (IEI) due to the relevance of MHC in the strength of the T cell responses.
View Article and Find Full Text PDFACS Appl Bio Mater
January 2025
Institute of Physics and Materials Science, Department of Natural Sciences and Sustainable Ressources, BOKU University, Peter Jordan-Straß 82, 1190 Vienna, Austria.
Spider silk (SPSI) is a promising candidate for use as a filler material in nerve guidance conduits (NGCs), facilitating peripheral nerve regeneration by providing a scaffold for Schwann cells (SCs) and axonal growth. However, the specific properties of SPSI that contribute to its regenerative success remain unclear. In this study, the egg sac silk of is investigated, which contains two distinct fiber types: tubuliform (TU) and major ampullate (MA) silk.
View Article and Find Full Text PDFNature
January 2025
Immuno-Oncology Service, Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Tertiary lymphoid structures (TLSs) are de novo ectopic lymphoid aggregates that regulate immunity in chronically inflamed tissues, including tumours. Although TLSs form due to inflammation-triggered activation of the lymphotoxin (LT)-LTβ receptor (LTβR) pathway, the inflammatory signals and cells that induce TLSs remain incompletely identified. Here we show that interleukin-33 (IL-33), the alarmin released by inflamed tissues, induces TLSs.
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