AI Article Synopsis
- Developed a new method for creating 2,5-dialkyl-4,6,7-tricyanoindole derivatives using a base-catalyzed reaction.
- The process involves condensing two fumaronitrile molecules with one 1,3-diketone molecule.
- This reaction efficiently cleaves a specific carbon bond in the diketone and forms several new bonds, generating both aryl and pyrrole rings of the indole in a single step.
Article Abstract
We describe a novel method to synthesize 2,5-dialkyl-4,6,7-tricyanoindole derivatives from a base-catalyzed reaction of 1,3-diketones with fumaronitrile. The reaction proceeds by the condensation of two molecules of fumaronitrile and one molecule of 1,3-diketone in a remarkable process that involves the cleavage of one C(sp)-C(sp) bond in 1,3-diketones and the formation of one carbon-nitrogen bond and four carbon-carbon bonds to construct both the aryl and pyrrole rings of the indole in one step.
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| http://dx.doi.org/10.1021/acs.orglett.0c01057 | DOI Listing |
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