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http://dx.doi.org/10.1097/NCM.0000000000000433 | DOI Listing |
Eur J Pharmacol
January 2025
State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica & Neuroscience Center, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, 100050, China; Hunan University of Traditional Chinese Medicine & Hunan Engineering Technology Center of Standardization and Function of Chinese Herbal Decoction Pieces, Changsha, 410208, Hunan, China. Electronic address:
Background: Depression is a leading chronic mental illness worldwide, characterized by anhedonia and pessimism. Connexin is a kind of widely distributed protein in the body. Connexin 43 (Cx43) plays an important role in the pathogenesis of depression.
View Article and Find Full Text PDFProc Natl Acad Sci U S A
December 2024
Department of Mechanical Engineering and Applied Mechanics, University of Pennsylvania, Philadelphia, PA 19104.
Many microorganisms exhibit upstream swimming, which is important to many biological processes and can cause contamination of biomedical devices and the infection of organs. This process, called rheotaxis, has been studied extensively in Newtonian fluids. However, most microorganisms thrive in non-Newtonian fluids that contain suspended polymers such as mucus and biofilms.
View Article and Find Full Text PDFInt Immunopharmacol
January 2025
College of Integrated Chinese and Western Medicine, Anhui University of Chinese Medicine, Hefei 230012, China; Research Center of Integrated Traditional Chinese and Western Medicine, Wannan Medical College, Wuhu 241002, China. Electronic address:
Background: Chronic obstructive pulmonary disease (COPD) is characterized for the persistent inflammation. The brain and muscle arnt-like 1 (BMAL1), as a crucial clock gene, is associated with the expression level of upstream factor hypoxia-inducible factor (HIF)-1α in glycolysis, which may affect the occurrence of inflammatory reactions in COPD. However, the moderation effect of Qibai Pingfei Capsule (QBPF) capsule is still unknown on BMAL1 and HIF-1α/glycolytic pathway.
View Article and Find Full Text PDFSci Rep
October 2024
Department of Natural Resources and Environmental Sciences, University of Illinois Urbana-Champaign, Champaign, IL, 61801, USA.
One of the hallmarks of invasive species is their propensity to spread. Removing an invasive species after establishment is virtually impossible, and so considerable effort is invested in preventing the range expansion of invaders. Silver carp (Hypophthalmichthys molitrix) were discovered in the Mississippi River in 1981 and have spread throughout the basin.
View Article and Find Full Text PDFSci Rep
October 2024
Whitman Center, Marine Biological Laboratory, Woods Hole, MA, 02543, USA.
Free-swimming polychaetes are common in marine habitats and exhibit a unique form of swimming whereby a metachronal wave occurs simultaneously with a bending body wave. This body wave is unusual among swimming animals because it travels in the same direction as the animal's swimming direction. However, we currently lack a mechanistic understanding of this unusual form of locomotion.
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