Although several studies have suggested that negative aspects of relationships have a greater impact on mood than positive elements, the individuals in these studies have been victims of life crises. To assess the generality of these findings, social support and mood data were collected from two well-matched groups that differed with respect to the presence of a chronic stressor in their lives. The 34 family care-givers for Alzheimer's disease victims and 34 comparison persons (non-care-givers) did not differ in the frequency of contacts, the closeness of their relationships, or ratings of the helpfulness or upset associated with the relationships. However, while upset accounted for a significant portion of the variance in care-givers' depressive symptoms in regression equations, neither upset nor helpfulness was significantly related to mood in non-care-givers. Care-givers whose relatives had more symptomatic Alzheimer's disease behaviors were more distressed and described their relationships with others as more upsetting. Implications for interventions and for the contextual importance of upsetting or negative support are discussed.
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http://dx.doi.org/10.1007/BF00930895 | DOI Listing |
Adv Sci (Weinh)
January 2025
Institute of Medicinal Biotechnology, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, 100050, P. R. China.
MicroRNAs (miRNAs) are associated with amyloid-β (Aβ) dysmetabolism, a pivotal factor in the pathogenesis of Alzheimer's disease (AD). This study unveiled a novel miRNA, microRNA-32533 (miR-32533), featuring a distinctive base sequence identified through RNA sequencing of the APPswe/PSEN1dE9 (APP/PS1) mouse brain. Its role and underlying mechanisms were subsequently explored.
View Article and Find Full Text PDFMol Nutr Food Res
January 2025
Institutes of Biomedical Sciences, School of Medicine, Jianghan University, Wuhan, China.
Scope: Alzheimer's disease (AD) is the most prevalent form of dementia, lack of effective therapeutic interventions. In this study, we investigate the impact of intermittent fasting (IF), an alternative strategy of calorie restriction, on cognitive functions and AD-like pathology in a transgenic mouse model of AD.
Methods And Results: APP/PS1 mice at 6 months were randomly allocated to two dietary groups: one receiving ad libitum (AL) feeding and the other undergoing IF for 1 month.
Geriatr Psychol Neuropsychiatr Vieil
September 2024
CMRR CHU Toulouse, IHU Health Age, Toulouse, UMR 1297 CERPOP.
The growing prevalence of the Alzheimer's disease (AD) is an increasing public health concern that led to French recommendations for timely AD diagnosis and patient management as well as a territorial coverage of specialized structures [Memory Centers including Resources and Memory Research Centers (RMRC) and Memory Consultations (MC)]. In view of the potential availability of Disease Modifying Therapies (DMTs), this French observatory aimed to describe the current organization of the Memory Centers, and the care pathway of patients suffering from early AD. Overall, 12 of the 28 RMRC and 44 of the 250 MC solicited by the Federation of Memory Centers participated in this study.
View Article and Find Full Text PDFFront Dement
January 2025
Department of Internal Medicine, American University of Beirut Medical Center, Beirut, Lebanon.
Objective: To provide the first estimates of dementia incidence rates among elderly in Lebanon.
Methods: The cohort established in 2013 consisted of 470 elderly from Beirut and Mount Lebanon, who consented to be followed-up. In 2017, we reached 341 participants/informants, achieving a response rate of 72.
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