Automatic classification of brain tumor types is very important for accelerating the treatment process, planning and increasing the patient's survival rate. Today, MR images are used to determine the type of brain tumor. Manual diagnosis of brain tumor type depends on the experience and sensitivity of radiologists. Therefore, researchers have developed many brain tumor classification models to minimize the human factor. In this study, two different feature extraction (nLBP and αLBP) approaches were used to classify the most common brain tumor types; Glioma, Meningioma, and Pituitary brain tumors. nLBP is formed based on the relationship for each pixel around the neighbors. The nLBP method has a d parameter that specifies the distance between consecutive neighbors for comparison. Different patterns are obtained for different d parameter values. The αLBP operator calculates the value of each pixel based on an angle value. The angle values used for calculation are 0, 45, 90 and 135. To test the proposed methods, it was applied to images obtained from the brain tumor database collected from Nanfang Hospital, Guangzhou, China, and Tianjin Medical University General Hospital between the years of 2005 and 2010. The classification process was performed by using K-Nearest Neighbor (Knn) and Artificial Neural Networks (ANN), Random Forest (RF), A1DE, Linear Discriminant Analysis (LDA) classification methods, with the feature matrices obtained with nLBP, αLBP and classical LBP from the images in the data set. The highest success rate in brain tumor classification was 95.56% with the nLBPd = 1 feature extraction method and Knn model.
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http://dx.doi.org/10.1016/j.mehy.2020.109696 | DOI Listing |
J Med Chem
January 2025
School of Pharmacy, College of Pharmacy, Taipei Medical University, Taipei 110, Taiwan.
Since decades after temozolomide was approved, no effective drugs have been developed. Undoubtedly, blood-brain barrier (BBB) penetration is a severe issue that should be overcome in glioblastoma multiforme (GBM) drug development. In this research, we were inspired by linezolid through structural modification with several bioactive moieties to achieve the desired brain delivery.
View Article and Find Full Text PDFMol Biol Rep
January 2025
Molecular Genetics and Cancer Biology Laboratory, Department of Human Genetics and Molecular Biology, Bharathiar University, Coimbatore-46, Tamil Nadu, India.
Background: Electromagnetic radiation (EMR) from wireless technology and mobile phones, operates at various frequencies. The present study analyses the major impact of short-term exposure to 2.4 GHz frequency EMR, using the two model systems chick embryos and SH-SY5Y cell lines.
View Article and Find Full Text PDFMol Biol Rep
January 2025
Institute of Pathogenic Biology, Guilin Medical University, Guilin, 541199, China.
Cyclin-dependent kinase 5 (CDK5), a unique member of the CDK family, is a proline-directed serine/threonine protein kinase with critical roles in various physiological and pathological processes. Widely expressed in the central nervous system, CDK5 is strongly implicated in neurological diseases. Beyond its neurological roles, CDK5 is involved in metabolic disorders, psychiatric conditions, and tumor progression, contributing to processes such as proliferation, migration, immune evasion, genomic stability, and angiogenesis.
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January 2025
Department of Computer Applications, Kalasalingam Academy of Research and Education - Deemed to be University, Krishnankoil, India.
Brain tumors can cause difficulties in normal brain function and are capable of developing in various regions of the brain. Malignant tumours can develop quickly, pass through neighboring tissues, and extend to further brain regions or the central nervous system. In contrast, healthy tumors typically develop slowly and do not invade surrounding tissues.
View Article and Find Full Text PDFElife
January 2025
Department of Neurology, Weill Institute for Neuroscience, University of California San Francisco, San Francisco, United States.
Mutations in Sonic Hedgehog (SHH) signaling pathway genes, for example, (SUFU), drive granule neuron precursors (GNP) to form medulloblastomas (MB). However, how different molecular lesions in the Shh pathway drive transformation is frequently unclear, and mutations in the cerebellum seem distinct. In this study, we show that fibroblast growth factor 5 (FGF5) signaling is integral for many infantile MB cases and that expression is uniquely upregulated in infantile MB tumors.
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