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A Sorghum / Homolog Functions in PAMP-Triggered Immunity and Cell Death in Response to Infection.
Phytopathology
January 2025
University of Florida, Microbiology & Cell Science, Cancer/Genetics Research Complex 302, 2033 Mowry Road, Gainesville, Florida, United States, 32610;
(L.) Moench is the fifth most important cereal crop and expected to gain prominence due to its versatility, low input requirements, and tolerance to hot and dry conditions. In warm and humid environments the productivity of sorghum is severely limited by the hemibiotrophic fungal pathogen , the causal agent of anthracnose.
View Article and Find Full Text PDFLncLSTA: a versatile predictor unveiling subcellular localization of lncRNAs through long-short term attention.
Bioinform Adv
November 2024
School of Information Engineering, Huzhou University, Huzhou, Zhejiang 313000, China.
Motivation: Much evidence suggests that the subcellular localization of long-stranded noncoding RNAs (LncRNAs) provides key insights for the study of their biological function.
Results: This study proposes a novel deep learning framework, LncLSTA, designed for predicting the subcellular localization of LncRNAs. It firstly exploits LncRNA sequence, electron-ion interaction pseudopotentials, and nucleotide chemical property as feature inputs.
Generation and characterization of CRISPR-Cas9-mediated XPC gene knockout in human skin cells.
Sci Rep
December 2024
Univ. Grenoble Alpes, CEA, Inserm, IRIG, UA13 BGE, Biomics, Grenoble, 38000, France.
Xeroderma pigmentosum group C (XPC) is a versatile protein crucial for sensing DNA damage in the global genome nucleotide excision repair (GG-NER) pathway. This pathway is vital for mammalian cells, acting as their essential approach for repairing DNA lesions stemming from interactions with environmental factors, such as exposure to ultraviolet (UV) radiation from the sun. Loss-of-function mutations in the XPC gene confer a photosensitive phenotype in XP-C patients, resulting in the accumulation of unrepaired UV-induced DNA damage.
View Article and Find Full Text PDFEffective multicolor visual biosensor for ochratoxin A detection enabled by DNAzyme catalysis and gold nanorod etching.
Mikrochim Acta
December 2024
Key Laboratory of Chemical Sensing & Analysis in Universities of Shandong, School of Chemistry and Chemical Engineering, University of Jinan, Jinan, 250022, People's Republic of China.
A novel detection technique is introduced that offers sensitive and reliable ochratoxin A (OTA) detection. The method leverages the etching of gold nanorods (AuNRs) stabilized by hexadecyl trimethyl ammonium bromide (CTAB) using the oxidized form of 3,3',5,5'-tetramethyl benzidine sulfate (TMB), creating a susceptible multicolor visual detection system for OTA. The visual detection is enabled by Mg-assisted DNAzyme catalysis combined with the catalytic hairpin assembly (CHA) signal amplification strategy.
View Article and Find Full Text PDFA population genomics approach to unlock the genetic potential of lablab (Lablab purpureus (L.) Sweet), an underutilized tropical forage crop.
BMC Genomics
December 2024
Feed and Forage Development, International Livestock Research Institute, Addis Ababa, Ethiopia.
Background: Lablab is one of the conventionally grown multi-purpose crops that originated in Africa. It is an annual or short-lived perennial forage legume which has versatile uses (as a vegetable and dry seeds, as food or feed, or as green manure) but is yet to receive adequate research attention and hence remains underexploited. To develop new and highly productive lablab varieties, using genomics-assisted selection, the present study aimed to identify quantitative trait loci associated with agronomically important traits in lablab and to assess the stability of these traits across two different agro-ecologies in Ethiopia.
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