Creutzfeldt-Jakob disease (CJD) is a prion disease characterized by rapidly progressive dementia that is often followed by behavioral disturbances, ataxia, myoclonus, and akinetic mutism. The initial symptoms of CJD reportedly vary, but the onset is usually gradual. Here, we report a case of CJD with a sudden, stroke-like onset of right hemiparesis to alert readers that CJD can mimic a stroke during its early stage.
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| http://dx.doi.org/10.1016/j.jstrokecerebrovasdis.2020.104788 | DOI Listing |
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Department of Neurology, College of Medicine, King Fahd University Hospital, Imam Abdulrahman Bin Faisal University, Dammam, 34212, Kingdom of Saudi Arabia.
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Unit of Medical and Dental Sciences, Department of Health Sciences, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki 852-8501, Japan.
Prion diseases are fatal neurological disorders characterized by abnormal protein accumulation in the brain, leading to neurodegeneration, dementia, and ataxia. Sporadic Creutzfeldt-Jakob disease (sCJD), the most common form, accounts for 80-90% of cases and progresses rapidly, with most patients surviving <6 months to a year after symptom onset, indicating the importance of early diagnosis. The disease is classified into six subtypes based on PRNP gene polymorphisms, with differences in protein degradation patterns contributing to the diversity of clinical symptoms.
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Shahid Beheshti University of Medical Sciences, Tehran, Iran. Electronic address:
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View Article and Find Full Text PDF[Adult leukoencephalopathy with axonal spheroids and pigmented glia].
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