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| http://dx.doi.org/10.1176/appi.ajp.2019.19080845 | DOI Listing |
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Modifying reaction time tasks parameters in the automated IntelliCage identifies heightened impulsivity and impaired attention in the 3xTg-AD model of Alzheimer's disease.
Front Aging Neurosci
December 2024
Arizona State University-Banner Neurodegenerative Disease Research Center at the Biodesign Institute, Arizona State University, Tempe, AZ, United States.
Background: The 3xTg-AD transgenic mouse model of Alzheimer's disease (AD) is an important tool to investigate the relationship between development of pathological amyloid-β (Aβ) and tau, neuroinflammation, and cognitive impairments. Traditional behavioral tasks assessing aspects of learning and memory, such as mazes requiring spatial navigation, unfortunately suffer from several shortcomings, including the stress of human handling and not probing species-typical behavior. The automated IntelliCage system was developed to circumvent such issues by testing mice in a social environment while measuring multiple aspects of cognition.
View Article and Find Full Text PDFAssessing serial recall as a measure of artificial grammar learning.
Front Psychol
December 2024
Department of Psychology, Emory University, Atlanta, GA, United States.
Introduction: Implicit statistical learning is, by definition, learning that occurs without conscious awareness. However, measures that putatively assess implicit statistical learning often require explicit reflection, for example, deciding if a sequence is 'grammatical' or 'ungrammatical'. By contrast, 'processing-based' tasks can measure learning without requiring conscious reflection, by measuring processes that are facilitated by implicit statistical learning.
View Article and Find Full Text PDFNeurocognition and affective temperament in first-degree relatives of patients with bipolar disorder in south India: a cross-sectional study.
East Asian Arch Psychiatry
December 2024
Department of Pathology, All India Institute of Medical Sciences-Madurai, Ramanthapuram, Tamil Nadu, India.
Background: Endophenotypes aid in studying the complex genetic basis of bipolar disorder. We aimed to compare first-degree relatives of patients with bipolar I disorder in a hospital in India with unrelated healthy controls in terms of neurocognition and affective temperament METHODS. This cross-sectional study was conducted between August and November 2012 at a tertiary hospital in India.
View Article and Find Full Text PDFVisual short-term memory binding and attentional processes during object-scene integration are preserved in mild cognitive impairment.
Cortex
December 2024
Department of Psychology, Sapienza University of Rome, Rome, Italy; IRCCS Fondazione Santa Lucia, Rome, Italy. Electronic address:
Binding, a critical cognitive process likely mediated by attention, is essential for creating coherent object representations within a scene. This process is vulnerable in individuals with dementia, who exhibit deficits in visual working memory (VWM) binding, primarily tested using abstract arrays of standalone objects. To explore how binding operates in more realistic settings across the lifespan, we examined the impact of object saliency and semantic consistency on VWM binding and the role of overt attention.
View Article and Find Full Text PDFVAE-IF: Deep feature extraction with averaging for fully unsupervised artifact detection in routinely acquired ICU time-series.
Comput Biol Med
December 2024
Institute for Imaging, Data and Communications (IDCOM), School of Engineering, University of Edinburgh, Edinburgh, EH9 3FB, UK.
Artifacts are a common problem in physiological time series collected from intensive care units (ICU) and other settings. They affect the quality and reliability of clinical research and patient care. Manual annotation of artifacts is costly and time-consuming, rendering it impractical.
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