The traditional label propagation algorithm (LPA) iteratively propagates labels from a small number of labeled samples to many unlabeled ones based on the sample similarities. However, due to the randomness of label propagations, and LPA's weak ability to deal with uncertain points, the label error may be continuously expanded during the propagation process. In this paper, the algorithm label propagation based on roll-back detection and credibility assessment (LPRC) is proposed. A credit evaluation of the unlabeled samples is carried out before the selection of samples in each round of label propagation, which makes sure that the samples with more certainty can be labeled first. Furthermore, a roll-back detection mechanism is introduced in the iterative process to improve the label propagation accuracy. At last, our method is compared with 9 algorithms based on UCI datasets, and the results demonstrated that our method can achieve better classification performance, especially when the number of labeled samples is small. When the labeled samples only account for 1% of the total sample number of each synthetic dataset, the classification accuracy of LPRC improved by at least 26.31% in dataset circles, and more than 13.99%, 15.22% than most of the algorithms compared in dataset moons and varied, respectively. When the labeled samples account for 2% of the total sample number of each dataset in UCI datasets, the accuracy (take the average value of 50 experiments) of LPRC improved in an average value of 23.20% in dataset wine, 20.82% in dataset iris, 4.25% in dataset australian, and 6.75% in dataset breast. And the accuracy increases with the number of labeled samples.
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http://dx.doi.org/10.3934/mbe.2020132 | DOI Listing |
Thromb Haemost
January 2025
Department of Medical Physiology, Hamamatsu University School of Medicine, Hamamatsu, Japan.
Background: Fibrinolysis is spatiotemporally well-regulated and greatly influenced by activated platelets and coagulation activity. Our previous real-time imaging analyses revealed that clotting commences on activated platelet surfaces, resulting in uneven-density fibrin structures, and that fibrinolysis initiates in dense fibrin regions and extends to the periphery. Despite the widespread clinical use of direct oral anticoagulants (DOACs), their impact on thrombin-dependent activation of thrombin-activatable fibrinolysis inhibitor (TAFI) and fibrinolysis remains unclear.
View Article and Find Full Text PDFBackground: Neuroinflammation is an integral part of Alzheimer's Disease (AD) pathology, whereby inflammatory processes contribute to the production of amyloid-β, the propagation of tau pathology, and neuronal loss. We recently investigated data-driven methods for determining distinct progression trajectory groups on the ADCOMS scale. This study evaluates whether biomarkers of inflammation in cerebrospinal fluid (CSF) can predict progression rate and membership of those progression rate groups.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
Washington University School of Medicine, St. Louis, MO, USA.
Background: Alzheimer's disease neuropathology involves the deposition in brain of aggregates enriched with microtubule-binding-region (MTBR) of tau adopting an abnormal conformation between residues 306-378 in the core of aggregates. Anti-tau drugs targeting around this domain have the potential to interfere with the cell-to-cell propagation of pathological tau. Bepranemab is a humanized monoclonal Ig4 antibody binding to tau residues 235-250.
View Article and Find Full Text PDFNeural Netw
January 2025
Chongqing Key Laboratory of Computational Intelligence, Chongqing University of Posts and Telecommunications, Chongqing, 400065, China; College of Computer and Information Science, Chongqing Normal University, Chongqing, 401331, China. Electronic address:
The production of expressive molecular representations with scarce labeled data is challenging for AI-driven drug discovery. Mainstream studies often follow a pipeline that pre-trains a specific molecular encoder and then fine-tunes it. However, the significant challenges of these methods are (1) neglecting the propagation of diverse information within molecules and (2) the absence of knowledge and chemical constraints in the pre-training strategy.
View Article and Find Full Text PDFPharmacoepidemiol Drug Saf
January 2025
Hunan Institute for Drug Control, Changsha, Hunan, China.
Background And Objectives: Based on the Adverse Event Reporting System (FAERS) data from the US FDA, this study mined the adverse drug reactions of obeticholic acid (OCA) in the real world and provided reference for clinical safe drug use.
Methods: Adverse event reports for OCA from the second quarter of 2016 to the third quarter of 2023 were extracted. The analysis for adverse reaction signal detection was conducted using reporting odds ratio, proportional reporting ratio, Bayesian confidence propagation neural network, and multi-item gamma Poisson shrinker methods.
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