Analysis of a generalized Fujikawa's growth model.

We analyze a generalized form of the Fujikawas growth model which involves an adaptation function that enhances the representation of the lag phase. This model is autonomous, and combines a power law term, a saturation term and an adaptation function that suppresses the growth rate during initial period corresponding to the lag phase. The properties of the adaptation function are determined, and the proposed model is examined separately for the regular measure and the logarithmic measure, including: Convergence and boundedness properties; population at the inflection point; conditions for the existence of the inflection point and lag phase; effect of model parameters on the existence of the inflection point and lag phase; population size of the inflection point under limiting values of the model parameters; and parameter values that lead to inflection point located at the mean value of the curve. Different combinations of model parameters lead to different possibilities for the existence of the inflection point and the lag phase. It was noticed that the power law term has a strong effect on the representation of the exponential growth phase, whereas the adaptation function has a strong effect on the representation of the lag phase. The lag phase duration depends on the exponent parameter of the adaptation function, and its dependence with respect to the power law parameter is low. Also, an approach is proposed for the analytical determination of the lag time, based on the application of the classical approach to a simplified model. Ascertained lag time values were obtained, what confirms the assumptions. At last, the model is applied to experimental data.