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Incisional PSMA PET/CT-positive recurrences in prostate cancer- is there an implication on clinical care?
Clin Exp Metastasis
January 2025
Martini-Klinik Prostate Cancer Center, University Hospital Hamburg-Eppendorf, Hamburg, Germany.
Oligorecurrent prostate cancer (PCa) can be treated with metastasis-directed therapy (MDT), which may be performed using radioguided surgery (RGS) as an experimental approach. These procedures have shown promising outcomes, largely due to the high lesion detection rate of positron emission tomography/computed tomography (PET/CT). We present a case series of patients who underwent RGS following robot-assisted radical prostatectomy (RARP).
View Article and Find Full Text PDFWastewater microbiology: occurrence and prevalence of antibiotic-resistant extended-spectrum -lactamase-producing Enterobacteriaceae in the district wastewater system.
J Water Health
January 2025
Department of Biology and Ecology, Faculty of Science, University of Kragujevac, Kragujevac 34000, Serbia.
Extended spectrum -lactamase (ESBL)-producing Enterobacteriaceae, including and , pose a serious risk to human health because of antibiotic resistance. Wastewater serves as a reservoir for these bacteria, contributing to the evolution and transmission of antibiotic-resistant strains. The research aims to identify ESBL bacterium in wastewater samples from District Kohat.
View Article and Find Full Text PDFDevelopment of a multi-laboratory integrated predictive model for silicosis utilizing machine learning: a retrospective case-control study.
Front Public Health
January 2025
Department of Laboratory, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, China.
Objective: Due to the high global prevalence of silicosis and the ongoing challenges in its diagnosis, this pilot study aims to screen biomarkers from routine blood parameters and develop a multi-biomarker model for its early detection.
Methods: A case-control study was conducted to screen biomarkers for the diagnosis of silicosis using LASSO regression, SVM and RF. A sample of 612 subjects (half cases and half controls) were randomly divided into training and test groups in a 2:1 ratio.
Innovative antifungal strategies: enhanced biofilm inhibition of by a modified tea tree oil formulation.
Front Microbiol
January 2025
Faculty of Food and Biochemical Technology, University of Chemistry and Technology Prague, Prague, Czechia.
Introduction: is a significant human pathogen with the ability to form biofilms, a critical factor in its resistance to antifungal treatments. This study aims to evaluate the antifungal activity and biofilm inhibition potential of Tea Tree Oil (TTO) derived from cultivated in Vietnam.
Methods: The antifungal activity of TTO was assessed by determining the Minimum Inhibitory Concentration (MIC), Minimum Fungicidal Concentration (MFC), Minimum Biofilm Inhibitory Concentration (MBIC), and Minimum Biofilm Eradication Concentration (MBEC) using broth dilution methods.
Discrepancies Between Sex Prediction and Fetal Sex After Prenatal Noninvasive Cell-Free DNA Screening.
J Endocr Soc
January 2025
Department of Pathology, Stanford University, Stanford, CA 94304, USA.
In the last 10 years the field of prenatal diagnosis has been significantly reshaped followed by the implementation of noninvasive prenatal cell-free DNA (cfDNA) testing methodologies in clinical practice. Based on a superior performance and higher sensitivity and specificity than the former practice of biochemical markers screening, the American College of Obstetricians and Gynecologists and American College of Medical Genetics and Genomics recommend noninvasive prenatal cfDNA screening for trisomy 21, 18, 13, and sex chromosome aneuploidy to all pregnant people. While cfDNA screening is helpful in risk assessment for the most common autosomal trisomies, cfDNA also provides information about fetal sex chromosomes.
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