AI Article Synopsis
- - The study observed a rise in early-onset gastric carcinoma (GC) cases among young patients in China, focusing on 4,353 endoscopic gastroscopies conducted over five years, with a particular emphasis on ethnic distribution between Han and Yi minorities.
- - Among the 1,407 diagnosed GC cases, 171 (12%) were in patients aged 40 or younger, with a significant 54% being male and a high predominance (92%) from the Yi minority; the majority were classified as diffuse type (60%).
- - The study found familial clustering in 18% of cases but emphasized that further research is needed to identify non-genetic risk factors influencing the higher incidence of GC in these ethnic groups.
Article Abstract
Background: In China, the incidence of cancer has significantly decreased over the last two decades. In contrast, the incidence of gastric carcinoma (GC) has risen in young patients.
Methods: We reevaluated the histopathological results of 4,353 endoscopic gastroscopies from the Department of Pathology at No 1 Hospital of Liangshan. The ethnic groups Han and Yi were almost equally distributed in this cohort. Over a five-year period, 1407 GC were diagnosed.
Results: In 171 of these cases (12%), the patients were ≤40 years old (early-onset GC, EOGC). Out of this cohort, 9 patients were aged ≤25 years. 54% of these patients were male and showed marked predominance (92%) of the Yi-minority. Using the classification of Lauren, 103 GC (60%) were of diffuse type, 27 (16%) of intestinal type, and 41 (24%) of mixed type. In the remaining 1,236 cases of patients ≥41 years (88%), 1,014 patients (82%) belonged to the Yi-minority. (HP) were found in 46% of all cases. Familial clustering was found in 14 patients (18%; in first degree relatives, 12%, and in second degree relatives, 6%). Follow-up was not possible.
Conclusion: This study demonstrates the unequal manifestation of EOGC within the two ethnic groups of Han and Yi. However, familial clustering was infrequent. Further investigations are necessary to discover relevant risk factors apart from hereditary predisposition.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7085875 | PMC |
| http://dx.doi.org/10.1155/2020/6845413 | DOI Listing |
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