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Current Concepts in Pharmacometabolomics, Biomarker Discovery, and Precision Medicine. | LitMetric

AI Article Synopsis

  • Pharmacometabolomics (PMx) examines how an individual's metabolic profile, influenced by factors like genetics and health status, affects their response to drug treatments.* -
  • The individual metabolic profile, known as "metabotype," helps identify patterns in drug efficacy and can classify patients as responders or non-responders, aiding in precision medicine.* -
  • PMx research can facilitate the discovery of biomarkers during clinical trials, and these biomarkers can be submitted for FDA approval as outlined by the 21st Century Cures Act.*

Article Abstract

Pharmacometabolomics (PMx) studies use information contained in metabolic profiles (or metabolome) to inform about how a subject will respond to drug treatment. Genome, gut microbiome, sex, nutrition, age, stress, health status, and other factors can impact the metabolic profile of an individual. Some of these factors are known to influence the individual response to pharmaceutical compounds. An individual's metabolic profile has been referred to as his or her "metabotype." As such, metabolomic profiles obtained prior to, during, or after drug treatment could provide insights about drug mechanism of action and variation of response to treatment. Furthermore, there are several types of PMx studies that are used to discover and inform patterns associated with varied drug responses (i.e., responders vs. non-responders; slow or fast metabolizers). The PMx efforts could simultaneously provide information related to an individual's pharmacokinetic response during clinical trials and be used to predict patient response to drugs making pharmacometabolomic clinical research valuable for precision medicine. PMx biomarkers can also be discovered and validated during FDA clinical trials. Using biomarkers during medical development is described in US Law under the 21st Century Cures Act. Information on how to submit biomarkers to the FDA and their context of use is defined herein.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7241083PMC
http://dx.doi.org/10.3390/metabo10040129DOI Listing

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