AI Article Synopsis
- This study explores the role of microvascular tissue (mVASC) in promoting wound healing by examining its components and biological effects.
- mVASC was tested in both animal models and human chronic wounds, showing an increase in blood vessel formation and healing processes.
- The results suggest that utilizing microvascular tissue can enhance healing in difficult-to-treat wounds by supporting tissue repair mechanisms.
Article Abstract
Profiling of microvascular tissue allows identification of components that stimulate wound healing. Here we study those elements for biological effect and establish clinical proof-of-concept using a microvascular tissue graft (mVASC) in chronic refractory wounds. mVASC was characterized for tissue fragments and protein composition, evaluated for angiogenic potential in preclinical models, and applied clinically to a series of nonhealing wounds with compromised vascularity of different etiologies. mVASC increased endothelial cell migration and angiogenesis in mouse ingrowth and hindlimb ischemia models. Clinically, mVASC stimulated wound neovascularization, granulation and epithelialization, and complete and durable healing. Microvascular tissue contains elements relevant to tissue repair and can be clinically applied to enable or accelerate the closure of challenging wounds.
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| http://dx.doi.org/10.2217/rme-2019-0139 | DOI Listing |
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