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Long-term forecast for antibacterial drug consumption in Germany using ARIMA models.
Naunyn Schmiedebergs Arch Pharmacol
January 2025
Hannover Medical School, Institute of Pharmacology, D-30625, Hannover, Germany.
Article Synopsis
- This study forecasts the consumption of the top ten antibacterial drugs in Germany until 2040, using historical prescription data and ARIMA models.
- The best model for forecasting is a simple random walk with drift (ARIMA(0,1,0)), while short-term predictions show minimal variation among complex models.
- Predictions indicate rising prescriptions for some drugs like amoxicillin, but declines for others, emphasizing the need for proactive healthcare planning to address potential shortages.
Antibiotic resistance in community-acquired urinary tract infections. Did the COVID-19 pandemic cause a change?
J Infect Dev Ctries
September 2024
Division of Allergy and Immunology, Department of Pediatrics; School of Medicine, University of Kyrenia, Kyrenia, Cyprus.
Article Synopsis
- The study evaluated antimicrobial resistance rates in urine cultures before and during the COVID-19 pandemic, analyzing data from 897 patients over six years.
- E. coli and K. pneumoniae were the primary bacteria identified, with increased resistance rates for antibiotics like cefixime and ceftriaxone during the pandemic.
- Factors such as male gender and ESBL positivity were linked to higher resistance rates, indicating a notable increase in antibiotic resistance among uropathogens during this period.
The effect of fluoride varnish application on colour change due to paediatric drug usage in polyacid-modified composite resin: an in vitro study.
Eur Arch Paediatr Dent
June 2024
Department of Pediatric Dentistry, Faculty of Dentistry, Zonguldak Bülent Ecevit University, Zonguldak, Turkey.
Objective: Colour stability is important in the long-term aesthetic success of restorative materials and is affected by both internal and external factors. Internal discolourations are due to the properties of the restorative materials. External discolourations can be associated with frequent consumption of food and beverages and the use of suspensions or syrups containing colourants/additives.
View Article and Find Full Text PDFEffects of extended oral antibiotic prophylaxis on surgical site infections after instrumented spinal fusion: a cohort study of 901 patients with a minimum follow-up of 1 year.
Acta Orthop
February 2023
Spine Surgery Unit, Department of Trauma and Orthopaedics, Hospital Universitario de Navarra, Pamplona (Navarra).
Background And Purpose: We aimed to determine whether an extended oral antibiotic prophylaxis protocol may reduce the rate of surgical site infection (SSI) in patients undergoing instrumented spinal fusion.
Patients And Methods: This retrospective cohort study comprise 901 consecutive patients subjected to spinal fusion between September 2011 and December 2018 with a minimum 1-year follow-up. 368 patients operated on between September 2011 and August 2014 were administered standard intravenous prophylaxis.
A comparative performance evaluation of cephalosporin's drugs for fluoride recognition.
Anal Sci
April 2023
Srinivas Institute of Medical Sciences and Research Centre, Mangalore, Karnataka, 574146, India.
In this manuscript, readily available cephalosporin's drugs cefuroxime axetil (L1) cefpdoxime proxetil (L2), and cefditoren pivoxil (L3) possess dihydrothiazine ring as signaling unit, and -NH groups as the binding site were used for the sensing of fluoride (F) ions. In the presence of F, the drug selectively portrayed a naked-eye detectable color change from colorless. The binding constant of 1:1 stoichiometric complex of L1, L2, and L3 with F was found to be 2.
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