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Emotion processing of facial affect expression in patients with somatic symptom disorder with predominant pain-An EEG-study.
Neuroimage
January 2025
Department of Psychosomatic Medicine and Psychotherapy, Medical Faculty, Heinrich-Heine University Duesseldorf, Bergische Landstraße 2, 40629 Duesseldorf, Germany.
Despite their high prevalence, somatoform pain disorders are often not recognized early enough, not diagnosed reliably enough and not treated appropriately. Patients often experience a high level of suffering and the feeling of not being understood. For the medical care system, the symptoms represent a diagnostic and therapeutic challenge.
View Article and Find Full Text PDFVacuoles, E1 enzyme, X-linked, autoinflammatory, somatic (VEXAS) syndrome in a patient with subacute cutaneous lupus (SCLE).
BMJ Case Rep
January 2025
Rheumatology, University of Michigan Michigan Medicine, Ann Arbor, Michigan, USA
A man in his 60s suffered from refractory, biopsy-proven subacute cutaneous lupus erythematosus that required chronic, moderate dose steroids to manage. His rash was accompanied by arthralgias and negative autoantibody testing. His subacute lupus erythematosus (SCLE) was responsive to tofacitinib, but thrombotic complications limited the use of this medication.
View Article and Find Full Text PDFGLN2 as a key biomarker and therapeutic target: evidence from a comprehensive pan-cancer study using molecular, functional, and bioinformatic analyses.
Discov Oncol
November 2024
Department of Oncology, The First Affiliated Hospital of Anhui Medical University, Hefei, 230001, Anhui, China.
Background: GNL2, a nuclear protein, is involved in ribosome production and cell cycle regulation. However, its expression and function in different types of tumors are not well understood. Comprehensive studies across multiple cancer types are needed to assess the potential of GNL2 as a diagnostic, prognostic, and immunological marker.
View Article and Find Full Text PDFLow-dose titrated amitriptyline as second-line treatment for adults with irritable bowel syndrome in primary care: the ATLANTIS RCT.
Health Technol Assess
October 2024
Clinical Trial Research Unit, Leeds Institute of Clinical Trials Research, School of Medicine, University of Leeds, Leeds, UK.
Article Synopsis
- - The study aims to assess the effectiveness and cost-efficiency of low-dose amitriptyline as a second-line treatment for patients with irritable bowel syndrome (IBS) in primary care, especially when first-line treatments fail.
- - Conducted as a pragmatic, double-blind, placebo-controlled trial across 55 general practices in England, the design included both quantitative outcomes and qualitative experiences from participants and general practitioners regarding the treatment.
- - Participants included adults over 18 diagnosed with IBS who did not respond to initial therapies; they received either amitriptyline or a placebo for 6 months, with a focus on measuring the difference in IBS symptoms to see if the medication has a significant impact.
Fluctuations in somatic cell count and their impact on individual goat milk quality throughout lactation.
J Dairy Sci
January 2025
Faculty of Chemistry, Biotechnology and Food Science (KBM), Norwegian University of Life Sciences, N-1432 Ås, Norway.
Somatic cell count is used by the dairy industry as an indicator of milk quality and udder health. However, in goats, its reliability is significantly masked by noninfectious variables such as the milk secretion process and physiological lactation changes. Additionally, notable individual variability between goats might exist.
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